biostudies-literatureUnknown11(23)Calder DInjectable hydrogels can support the body's innate healing capability by providing a temporary matrix for host cell ingrowth and neovascularization. The clinical adoption of current injectable systems remains low due to their cumbersome preparation requirements, device malfunction, product dislodgment during administration, and uncontrolled biological responses at the treatment site. To address these challenges, a fully synthetic and ready-to-use injectable biomaterial is engineered that forms an adhesive hydrogel that remains at the administration site regardless of defect anatomy. The product elicits a negligible local inflammatory response and fully resorbs into nontoxic components with minimal impact on internal organs. Preclinical animal studies confirm that the engineered hydrogel upAdvanced healthcare materialse2201714https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468498biostudies-literatureThermoresponsive and Injectable Hydrogel for Tissue Agnostic Regeneration.PMC11468498Calder DMaitz JChrzanowski WOng HXMenon VAYoung PMAhern BJLee KCanoy IAbrams TLean NESilva DMMaitz PTraini DOveissi FMahmoud RSMaleknia SFathi AKhademhosseini ATsai KHDehghani FWang YMontazerian HfalseThermoresponsive and Injectable Hydrogel for Tissue Agnostic Regeneration.Injectable hydrogels can support the body's innate healing capability by providing a temporary matrix for host cell ingrowth and neovascularization. The clinical adoption of current injectable systems remains low due to their cumbersome preparation requirements, device malfunction, product dislodgment during administration, and uncontrolled biological responses at the treatment site. To address these challenges, a fully synthetic and ready-to-use injectable biomaterial is engineered that forms an adhesive hydrogel that remains at the administration site regardless of defect anatomy. The product elicits a negligible local inflammatory response and fully resorbs into nontoxic components with minimal impact on internal organs. Preclinical animal studies confirm that the engineered hydrogel up2022-01-01T00:00:00Z2022 Dec2026-07-15T09:32:29.949Z2025-04-04T00:34:41.922ZS-EPMC114684983614858110.1002/adhm.202201714