biostudies-literatureGeng HRosetrees TrustBritish Heart FoundationMedical Research CouncilKarolinska InstitutetEuropean CommissionWellcome TrustBiotechnology and Biological Sciences Research Councile2301148https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468501biostudies-literatureUnknown12(27)The development of near-infrared light responsive conductive polymers provides a useful theranostic platform for malignant tumors by maximizing spatial resolution with deep tissue penetration for diagnosis and photothermal therapy. Herein, the self-assembly of ultrathin 2D polypyrrole nanosheets utilizing dopamine as a capping agent and a monolayer of octadecylamine as a template is demonstrated. The 2D polypyrrole-polydopamine nanostructure has tunable size distribution which shows strong absorption in the first and second near-infrared windows, enabling photoacoustic imaging and photothermal therapy. The hybrid double-layer is demonstrated to increase Raman intensity for 3D Raman imaging (up to two orders of magnitude enhancement and spatial resolution up to 1 µm). The acidic environmentAdvanced healthcare materialsHybrid Polypyrrole and Polydopamine Nanosheets for Precise Raman/Photoacoustic Imaging and Photothermal Therapy.PMC11468501FS/15/33/31608BB/M009513/1FS/SBSRF/21/31020RM/17/1/33377212937/Z/18/Z101028152MR/R026416/1Li XGeng HSun RGrigsby CLBrachi GStuckey DJMa YLupton EJStevens MMZhou KfalseHybrid Polypyrrole and Polydopamine Nanosheets for Precise Raman/Photoacoustic Imaging and Photothermal Therapy.The development of near-infrared light responsive conductive polymers provides a useful theranostic platform for malignant tumors by maximizing spatial resolution with deep tissue penetration for diagnosis and photothermal therapy. Herein, the self-assembly of ultrathin 2D polypyrrole nanosheets utilizing dopamine as a capping agent and a monolayer of octadecylamine as a template is demonstrated. The 2D polypyrrole-polydopamine nanostructure has tunable size distribution which shows strong absorption in the first and second near-infrared windows, enabling photoacoustic imaging and photothermal therapy. The hybrid double-layer is demonstrated to increase Raman intensity for 3D Raman imaging (up to two orders of magnitude enhancement and spatial resolution up to 1 µm). The acidic environment2023-01-01T00:00:00Z2023 Oct2026-07-15T13:12:28.882Z2025-04-06T12:29:51.065ZS-EPMC114685013716935110.1002/adhm.202301148