biostudies-literatureJin NResearch and Cultivation Program of Stomatological Hospital of Southern Medical UniversityNational Natural Science Foundation of ChinaChina Postdoctoral Science Foundation2018 Scientist Partners of China Medical University (CMU) and Shenyang Branch of Chinese Academy of SciencesKey Research & Development Project of Liaoning Provincee2400526https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468540biostudies-literatureUnknown13(16)The management of diabetic wounds (DWs) continues to pose a significant challenge in the field of medicine. DWs are primarily prevented from healing due to damage to macrophage efferocytosis and fibroblast dysfunction. Consequently, a treatment strategy that involves both immunoregulation and the promotion of extracellular matrix (ECM) formation holds promise for healing DWs. Nevertheless, existing treatment methods necessitate complex interventions and are associated with increased costs, for example, the use of cytokines and cell therapy, both of which have limited effectiveness. In this study, a new type of ruthenium (IV) oxide nanoparticles (RNPs)-laden hybrid hydrogel dressing with a double network of Pluronic F127 and F68 has been developed. Notably, the hybrid hydrogel demonstrates Advanced healthcare materialsPromoting Diabetic Wound Healing through a Hydrogel-Based Cascade Regulation Strategy of Fibroblast-Macrophage.PMC11468540823010268157183220182250822023M731547HZHB2018013PY2022005Jin NWang XWang ZTang XfalsePromoting Diabetic Wound Healing through a Hydrogel-Based Cascade Regulation Strategy of Fibroblast-Macrophage.The management of diabetic wounds (DWs) continues to pose a significant challenge in the field of medicine. DWs are primarily prevented from healing due to damage to macrophage efferocytosis and fibroblast dysfunction. Consequently, a treatment strategy that involves both immunoregulation and the promotion of extracellular matrix (ECM) formation holds promise for healing DWs. Nevertheless, existing treatment methods necessitate complex interventions and are associated with increased costs, for example, the use of cytokines and cell therapy, both of which have limited effectiveness. In this study, a new type of ruthenium (IV) oxide nanoparticles (RNPs)-laden hybrid hydrogel dressing with a double network of Pluronic F127 and F68 has been developed. Notably, the hybrid hydrogel demonstrates 2024-01-01T00:00:00Z2024 Jun2025-04-22T10:48:19.299Z2025-04-05T23:46:09.621ZS-EPMC114685403846997810.1002/adhm.202400526