biostudies-literatureXue SScience and Technology Commission of Shanghai MunicipalityShanghai Sailing Programe2304128https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468911biostudies-literatureUnknown13(16)Guided bone regeneration (GBR) is a well-established technique for preserving and enhancing alveolar ridge structures. Success in GBR relies on fulfilling the Primary wound closure, Angiogenesis, Space maintenance, and Stability (PASS) principles. Conventional methods, involving titanium meshes and sutures, have drawbacks, including the need for secondary removal and customization challenges. To address these issues, an innovative multifunctional GBR dressing (MGD) based on self-healing elastomer (PUIDS) is introduced. MGD provides sutureless wound closure, prevents food particle accumulation, and maintains a stable environment for bone growth. It offers biocompatibility, bactericidal properties, and effectiveness in an oral GBR model. In summary, MGD provides a reliable, stable osteogenicAdvanced healthcare materialsAnti-Wound Dehiscence and Antibacterial Dressing with Highly Efficient Self-Healing Feature for Guided Bone Regeneration Wound Closure.PMC1146891118DZ229030021DZ229170023YF1430200Xue STang NZhou CFang SHaick HSun JWu XfalseAnti-Wound Dehiscence and Antibacterial Dressing with Highly Efficient Self-Healing Feature for Guided Bone Regeneration Wound Closure.Guided bone regeneration (GBR) is a well-established technique for preserving and enhancing alveolar ridge structures. Success in GBR relies on fulfilling the Primary wound closure, Angiogenesis, Space maintenance, and Stability (PASS) principles. Conventional methods, involving titanium meshes and sutures, have drawbacks, including the need for secondary removal and customization challenges. To address these issues, an innovative multifunctional GBR dressing (MGD) based on self-healing elastomer (PUIDS) is introduced. MGD provides sutureless wound closure, prevents food particle accumulation, and maintains a stable environment for bone growth. It offers biocompatibility, bactericidal properties, and effectiveness in an oral GBR model. In summary, MGD provides a reliable, stable osteogenic2024-01-01T00:00:00Z2024 Jun2025-04-06T23:23:15.358Z2025-04-06T23:23:15.358ZS-EPMC114689113841137610.1002/adhm.202304128