{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stine JM"],"funding":["National Science Foundation"],"pagination":["e2302897"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468942"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(5)"],"pubmed_abstract":["Hydrogen sulfide (H<sub>2</sub> S) is a gaseous inflammatory mediator and important signaling molecule for maintaining gastrointestinal (GI) homeostasis. Excess intraluminal H<sub>2</sub> S in the GI tract has been implicated in inflammatory bowel disease and neurodegenerative disorders; however, the role of H<sub>2</sub> S in disease pathogenesis and progression is unclear. Herein, an electrochemical gas-sensing ingestible capsule is developed to enable real-time, wireless amperometric measurement of H<sub>2</sub> S in GI conditions. A gold (Au) three-electrode sensor is modified with a Nafion solid-polymer electrolyte (Nafion-Au) to enhance selectivity toward H<sub>2</sub> S in humid environments. The Nafion-Au sensor-integrated capsule shows a linear current response in H<sub>2</sub> S "],"journal":["Advanced healthcare materials"],"pubmed_title":["Miniaturized Capsule System Toward Real-Time Electrochemical Detection of H<sub>2</sub> S in the Gastrointestinal Tract."],"pmcid":["PMC11468942"],"funding_grant_id":["1939236"],"pubmed_authors":["Levy JA","Ghodssi R","Beardslee LA","Pasricha PJ","Abianeh H","Botasini S","Stine JM","Ruland KL"],"additional_accession":[]},"is_claimable":false,"name":"Miniaturized Capsule System Toward Real-Time Electrochemical Detection of H<sub>2</sub> S in the Gastrointestinal Tract.","description":"Hydrogen sulfide (H<sub>2</sub> S) is a gaseous inflammatory mediator and important signaling molecule for maintaining gastrointestinal (GI) homeostasis. Excess intraluminal H<sub>2</sub> S in the GI tract has been implicated in inflammatory bowel disease and neurodegenerative disorders; however, the role of H<sub>2</sub> S in disease pathogenesis and progression is unclear. Herein, an electrochemical gas-sensing ingestible capsule is developed to enable real-time, wireless amperometric measurement of H<sub>2</sub> S in GI conditions. A gold (Au) three-electrode sensor is modified with a Nafion solid-polymer electrolyte (Nafion-Au) to enhance selectivity toward H<sub>2</sub> S in humid environments. The Nafion-Au sensor-integrated capsule shows a linear current response in H<sub>2</sub> S ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-07-14T20:41:10.665Z","creation":"2025-04-05T23:44:29.182Z"},"accession":"S-EPMC11468942","cross_references":{"pubmed":["38035728"],"doi":["10.1002/adhm.202302897"]}}