{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou Y"],"funding":["National Natural Science Foundation of China"],"pagination":["e2300994"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468986"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(27)"],"pubmed_abstract":["Ferroptosis as programmed cell death received considerable attention in cancer research. Recently, studies have associated ferroptosis with photodynamic therapy (PDT) because PDT promotes glutathione (GSH) deletion, glutathione peroxidase 4 (GPX4) degradation, and lipid peroxide accumulation. However, PDT-induced ferroptosis may be potentially prevented by ferroptosis suppressor protein 1 (FSP1). To address this limitation, herein, a novel strategy is developed to trigger ferroptosis by PDT and FSP1 inhibition. For enhancement of this strategy, a photoresponsive nanocomplex, self-assembled by BODIPY-modified poly(amidoamine) (BMP), is utilized to stably encapsulate the inhibitor of FSP1 (iFSP1) and chlorin e6 (Ce6). The nanosystem promotes intracellular delivery, penetration, and accumulat"],"journal":["Advanced healthcare materials"],"pubmed_title":["Photo-Enhanced Synergistic Induction of Ferroptosis for Anti-Cancer Immunotherapy."],"pmcid":["PMC11468986"],"funding_grant_id":["82222903"],"pubmed_authors":["Liu J","Kang W","Chen K","Zhang Y","Xu A","Lin WK","Yang R","Wang W","Zhou Y","Cheng Y","Jin L"],"additional_accession":[]},"is_claimable":false,"name":"Photo-Enhanced Synergistic Induction of Ferroptosis for Anti-Cancer Immunotherapy.","description":"Ferroptosis as programmed cell death received considerable attention in cancer research. Recently, studies have associated ferroptosis with photodynamic therapy (PDT) because PDT promotes glutathione (GSH) deletion, glutathione peroxidase 4 (GPX4) degradation, and lipid peroxide accumulation. However, PDT-induced ferroptosis may be potentially prevented by ferroptosis suppressor protein 1 (FSP1). To address this limitation, herein, a novel strategy is developed to trigger ferroptosis by PDT and FSP1 inhibition. For enhancement of this strategy, a photoresponsive nanocomplex, self-assembled by BODIPY-modified poly(amidoamine) (BMP), is utilized to stably encapsulate the inhibitor of FSP1 (iFSP1) and chlorin e6 (Ce6). The nanosystem promotes intracellular delivery, penetration, and accumulat","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-06-08T06:23:36.432Z","creation":"2025-04-04T00:35:31.774Z"},"accession":"S-EPMC11468986","cross_references":{"pubmed":["37432874"],"doi":["10.1002/adhm.202300994"]}}