biostudies-literatureZhou YNational Natural Science Foundation of Chinae2300994https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468986biostudies-literatureUnknown12(27)Ferroptosis as programmed cell death received considerable attention in cancer research. Recently, studies have associated ferroptosis with photodynamic therapy (PDT) because PDT promotes glutathione (GSH) deletion, glutathione peroxidase 4 (GPX4) degradation, and lipid peroxide accumulation. However, PDT-induced ferroptosis may be potentially prevented by ferroptosis suppressor protein 1 (FSP1). To address this limitation, herein, a novel strategy is developed to trigger ferroptosis by PDT and FSP1 inhibition. For enhancement of this strategy, a photoresponsive nanocomplex, self-assembled by BODIPY-modified poly(amidoamine) (BMP), is utilized to stably encapsulate the inhibitor of FSP1 (iFSP1) and chlorin e6 (Ce6). The nanosystem promotes intracellular delivery, penetration, and accumulatAdvanced healthcare materialsPhoto-Enhanced Synergistic Induction of Ferroptosis for Anti-Cancer Immunotherapy.PMC1146898682222903Liu JKang WChen KZhang YXu ALin WKYang RWang WZhou YCheng YJin LfalsePhoto-Enhanced Synergistic Induction of Ferroptosis for Anti-Cancer Immunotherapy.Ferroptosis as programmed cell death received considerable attention in cancer research. Recently, studies have associated ferroptosis with photodynamic therapy (PDT) because PDT promotes glutathione (GSH) deletion, glutathione peroxidase 4 (GPX4) degradation, and lipid peroxide accumulation. However, PDT-induced ferroptosis may be potentially prevented by ferroptosis suppressor protein 1 (FSP1). To address this limitation, herein, a novel strategy is developed to trigger ferroptosis by PDT and FSP1 inhibition. For enhancement of this strategy, a photoresponsive nanocomplex, self-assembled by BODIPY-modified poly(amidoamine) (BMP), is utilized to stably encapsulate the inhibitor of FSP1 (iFSP1) and chlorin e6 (Ce6). The nanosystem promotes intracellular delivery, penetration, and accumulat2023-01-01T00:00:00Z2023 Oct2026-06-08T06:23:36.432Z2025-04-04T00:35:31.774ZS-EPMC114689863743287410.1002/adhm.202300994