{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guedes G"],"funding":["Academy of Finland","Fundação para a Ciência e Tecnologia","European Research Council","Finnish Culture Foundation"],"pagination":["e2007761"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468987"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(40)"],"pubmed_abstract":["Polyoxometalates are an emerging class of molecular clusters, with well-defined structures and chemical compositions that are produced through simple, low-cost, and highly reproducible methods. In particular, the wheel-shaped cluster {Mo<sub>154</sub> } is a promising photothermal agent due to its intervalence charge transfer transitions. However, its toxicity hinders its systemic administration, being the development of a localized delivery system still incipient. Herein, an injectable and self-healing hydrogel of easy preparation and administration is developed, incorporating both {Mo<sub>154</sub> } and doxorubicin for synergistic photothermal and chemotherapy applications. The hydrogel is composed of benzylaldehyde functionalized polyethylene glycol, poly(N-isopropylacrylamide) functio"],"journal":["Advanced materials (Deerfield Beach, Fla.)"],"pubmed_title":["Dual-Crosslinked Dynamic Hydrogel Incorporating {Mo&lt;sub&gt;154&lt;/sub&gt; } with pH and NIR Responsiveness for Chemo-Photothermal Therapy."],"pmcid":["PMC11468987"],"funding_grant_id":["331151","UIDP/50011/2020","IF/01533/2015","317042","331106","825020","P2020-PTDC-QEQ-QIN-5975-2014","UIDB/50011/2020","00201144"],"pubmed_authors":["Hietala S","Sousa FL","Pinto RJB","Santos HA","Guedes G","Wang S","Correia A","Fontana F","Linden J","Figueiredo P"],"additional_accession":[]},"is_claimable":false,"name":"Dual-Crosslinked Dynamic Hydrogel Incorporating {Mo&lt;sub&gt;154&lt;/sub&gt; } with pH and NIR Responsiveness for Chemo-Photothermal Therapy.","description":"Polyoxometalates are an emerging class of molecular clusters, with well-defined structures and chemical compositions that are produced through simple, low-cost, and highly reproducible methods. In particular, the wheel-shaped cluster {Mo<sub>154</sub> } is a promising photothermal agent due to its intervalence charge transfer transitions. However, its toxicity hinders its systemic administration, being the development of a localized delivery system still incipient. Herein, an injectable and self-healing hydrogel of easy preparation and administration is developed, incorporating both {Mo<sub>154</sub> } and doxorubicin for synergistic photothermal and chemotherapy applications. The hydrogel is composed of benzylaldehyde functionalized polyethylene glycol, poly(N-isopropylacrylamide) functio","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-22T10:56:22.62Z","creation":"2025-04-05T23:45:51.962Z"},"accession":"S-EPMC11468987","cross_references":{"pubmed":["34382257"],"doi":["10.1002/adma.202007761"]}}