biostudies-literatureGuedes GAcademy of FinlandFundação para a Ciência e TecnologiaEuropean Research CouncilFinnish Culture Foundatione2007761https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468987biostudies-literatureUnknown33(40)Polyoxometalates are an emerging class of molecular clusters, with well-defined structures and chemical compositions that are produced through simple, low-cost, and highly reproducible methods. In particular, the wheel-shaped cluster {Mo<sub>154</sub> } is a promising photothermal agent due to its intervalence charge transfer transitions. However, its toxicity hinders its systemic administration, being the development of a localized delivery system still incipient. Herein, an injectable and self-healing hydrogel of easy preparation and administration is developed, incorporating both {Mo<sub>154</sub> } and doxorubicin for synergistic photothermal and chemotherapy applications. The hydrogel is composed of benzylaldehyde functionalized polyethylene glycol, poly(N-isopropylacrylamide) functioAdvanced materials (Deerfield Beach, Fla.)Dual-Crosslinked Dynamic Hydrogel Incorporating {Mo<sub>154</sub> } with pH and NIR Responsiveness for Chemo-Photothermal Therapy.PMC11468987331151UIDP/50011/2020IF/01533/2015317042331106825020P2020-PTDC-QEQ-QIN-5975-2014UIDB/50011/202000201144Hietala SSousa FLPinto RJBSantos HAGuedes GWang SCorreia AFontana FLinden JFigueiredo PfalseDual-Crosslinked Dynamic Hydrogel Incorporating {Mo<sub>154</sub> } with pH and NIR Responsiveness for Chemo-Photothermal Therapy.Polyoxometalates are an emerging class of molecular clusters, with well-defined structures and chemical compositions that are produced through simple, low-cost, and highly reproducible methods. In particular, the wheel-shaped cluster {Mo<sub>154</sub> } is a promising photothermal agent due to its intervalence charge transfer transitions. However, its toxicity hinders its systemic administration, being the development of a localized delivery system still incipient. Herein, an injectable and self-healing hydrogel of easy preparation and administration is developed, incorporating both {Mo<sub>154</sub> } and doxorubicin for synergistic photothermal and chemotherapy applications. The hydrogel is composed of benzylaldehyde functionalized polyethylene glycol, poly(N-isopropylacrylamide) functio2021-01-01T00:00:00Z2021 Oct2025-04-22T10:56:22.62Z2025-04-05T23:45:51.962ZS-EPMC114689873438225710.1002/adma.202007761