{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Toita R"],"funding":["Niterra Co., Ltd.","Japan Society for the Promotion of Science"],"pagination":["e2302611"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468989"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(5)"],"pubmed_abstract":["Implantable biomaterials trigger foreign body reactions (FBRs), which reduces the functional life of medical devices and prevents effective tissue regeneration. Although existing therapeutic approaches can circumvent collagen-rich fibrotic encapsulation secondary to FBRs, they disrupt native tissue repair. Herein, a new surface engineering strategy in which an apoptotic-mimetic, immunomodulatory, phosphatidylserine liposome (PSL) is released from an implant coating to induce the formation of a macrophage phenotype that mitigates FBRs and improves tissue healing is described. PSL-multilayers constructed on implant surfaces via the layer-by-layer method release PSLs over a 1-month period. In rat muscles, poly(etheretherketone) (PEEK), a nondegradable polymer implant model, induces FBRs with "],"journal":["Advanced healthcare materials"],"pubmed_title":["Releasable, Immune-Instructive, Bioinspired Multilayer Coating Resists Implant-Induced Fibrosis while Accelerating Tissue Repair."],"pmcid":["PMC11468989"],"funding_grant_id":["JP18K12091","JP21H03833","JP23K18442"],"pubmed_authors":["Tsuchiya A","Kasahara S","Kang JH","Toita R","Kitamura M"],"additional_accession":[]},"is_claimable":false,"name":"Releasable, Immune-Instructive, Bioinspired Multilayer Coating Resists Implant-Induced Fibrosis while Accelerating Tissue Repair.","description":"Implantable biomaterials trigger foreign body reactions (FBRs), which reduces the functional life of medical devices and prevents effective tissue regeneration. Although existing therapeutic approaches can circumvent collagen-rich fibrotic encapsulation secondary to FBRs, they disrupt native tissue repair. Herein, a new surface engineering strategy in which an apoptotic-mimetic, immunomodulatory, phosphatidylserine liposome (PSL) is released from an implant coating to induce the formation of a macrophage phenotype that mitigates FBRs and improves tissue healing is described. PSL-multilayers constructed on implant surfaces via the layer-by-layer method release PSLs over a 1-month period. In rat muscles, poly(etheretherketone) (PEEK), a nondegradable polymer implant model, induces FBRs with ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-04T08:18:05.69Z","creation":"2025-04-04T08:18:05.69Z"},"accession":"S-EPMC11468989","cross_references":{"pubmed":["38095751"],"doi":["10.1002/adhm.202302611"]}}