{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kelly DJ"],"funding":["Henry Royce Institute for Advanced Materials","Royal Society Fellowship","European Research Council","EPSRC","Engineering and Physical Sciences Research Council (UK) EPSRC","European Commission H2020 ERC Starter grant EvoluTEM","Engineering and Physical Sciences Research Council"],"pagination":["e2100668"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11469232"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(29)"],"pubmed_abstract":["Liquid-phase transmission electron microscopy is used to study a wide range of chemical processes, where its unique combination of spatial and temporal resolution provides countless insights into nanoscale reaction dynamics. However, achieving sub-nanometer resolution has proved difficult due to limitations in the current liquid cell designs. Here, a novel experimental platform for in situ mixing using a specially developed 2D heterostructure-based liquid cell is presented. The technique facilitates in situ atomic resolution imaging and elemental analysis, with mixing achieved within the immediate viewing area via controllable nanofracture of an atomically thin separation membrane. This novel technique is used to investigate the time evolution of calcium carbonate synthesis, from the earli"],"journal":["Advanced materials (Deerfield Beach, Fla.)"],"pubmed_title":["In Situ TEM Imaging of Solution-Phase Chemical Reactions Using 2D-Heterostructure Mixing Cells."],"pmcid":["PMC11469232"],"funding_grant_id":["EP/S021531/1","EP/S019367/1","EP/M010619/1","715502","EP/P009050/1","EP/R00661X/1","EP/P025498/1","EP/P025021/1"],"pubmed_authors":["Zhou M","Gebauer D","Kelly DJ","Clark N","Gorbachev RV","Haigh SJ"],"additional_accession":[]},"is_claimable":false,"name":"In Situ TEM Imaging of Solution-Phase Chemical Reactions Using 2D-Heterostructure Mixing Cells.","description":"Liquid-phase transmission electron microscopy is used to study a wide range of chemical processes, where its unique combination of spatial and temporal resolution provides countless insights into nanoscale reaction dynamics. However, achieving sub-nanometer resolution has proved difficult due to limitations in the current liquid cell designs. Here, a novel experimental platform for in situ mixing using a specially developed 2D heterostructure-based liquid cell is presented. The technique facilitates in situ atomic resolution imaging and elemental analysis, with mixing achieved within the immediate viewing area via controllable nanofracture of an atomically thin separation membrane. This novel technique is used to investigate the time evolution of calcium carbonate synthesis, from the earli","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-06-08T06:23:55.456Z","creation":"2025-04-04T08:22:12.16Z"},"accession":"S-EPMC11469232","cross_references":{"pubmed":["34105199"],"doi":["10.1002/adma.202100668"]}}