{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Chen X"],"funding":["NIDDK NIH HHS"],"pubmed_abstract":["<h4>Objective</h4>Extracellular vesicle (EV) secretion and cargo composition are dysregulated in metabolic diseases. This study aimed to identify changes in the EV size profile and protein cargoes in diet-induced obesity following time-restricted feeding (TRF) and to establish the role of EVs in obesity-related metabolic responses.<h4>Methods</h4>Mice were fed a high-fat diet (HFD) for 18 weeks prior to being placed either ad libitum or a time-restricted feeding for an additional 10 weeks. Mice on a normal chow ad libitum served as the control. The TRF group had food available for 10 hours and fasted for 14 hours per day.<h4>Results</h4>The serum EV size profile and amount displayed sex- and age-dependent changes in HFD-induced obesity, with age reducing EV amounts. HFD decreased small EV "],"journal":["Research square"],"pagination":["rs.3.rs-4745029"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11469403"],"repository":["biostudies-literature"],"pubmed_title":["Serum Extracellular Vesicles Reveal Metabolic Responses to Time-Restricted Feeding in High Fat Diet-Induced Obesity in Male Mice."],"pmcid":["PMC11469403"],"funding_grant_id":["R01 DK123042"],"pubmed_authors":["Fu Q","Bushman T","Chen X","Zhang S","Lin TY"],"additional_accession":[]},"is_claimable":false,"name":"Serum Extracellular Vesicles Reveal Metabolic Responses to Time-Restricted Feeding in High Fat Diet-Induced Obesity in Male Mice.","description":"<h4>Objective</h4>Extracellular vesicle (EV) secretion and cargo composition are dysregulated in metabolic diseases. This study aimed to identify changes in the EV size profile and protein cargoes in diet-induced obesity following time-restricted feeding (TRF) and to establish the role of EVs in obesity-related metabolic responses.<h4>Methods</h4>Mice were fed a high-fat diet (HFD) for 18 weeks prior to being placed either ad libitum or a time-restricted feeding for an additional 10 weeks. Mice on a normal chow ad libitum served as the control. The TRF group had food available for 10 hours and fasted for 14 hours per day.<h4>Results</h4>The serum EV size profile and amount displayed sex- and age-dependent changes in HFD-induced obesity, with age reducing EV amounts. HFD decreased small EV ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-04T14:37:42.954Z","creation":"2025-04-04T14:37:42.954Z"},"accession":"S-EPMC11469403","cross_references":{"pubmed":["39399666"],"doi":["10.21203/rs.3.rs-4745029/v1"]}}