biostudies-literatureUnknown45(11)Fusetti CNextGenerationEU-MUR PNRR Extended Partnership initiative on Emerging Infectious DiseasesUniversità degli Studi di Milano<h4>Background</h4>Neurobrucellosis presents diverse clinical challenges and risks of long-term complications.<h4>Objective</h4>We aimed to assess the relationship between the duration of antibiotic therapy, clinical factors, and the outcome of neurobrucellosis with a case report combined with a systematic review of the literature.<h4>Methods</h4>We present a case of a 31 years-old man successfully treated at our Institution. We then searched Ovid MEDLINE, Embase and Scopus for articles that encompassed neurobrucellosis cases, duration of treatment, and outcome. The primary outcome was to assess an association between the duration of treatment and the risk of sequelae or relapses. Univariate, multivariate and sensitivity analysis were carried out to define which variables affect​ed​ the clNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology5441-5448https://www.ebi.ac.uk/biostudies/studies/S-EPMC11470871biostudies-literatureNeurobrucellosis Presenting with Motor Damage or Hearing Loss, and Use of Steroids are Associated with a Higher Risk of Sequelae or Relapse: A Systematic Review of Individual Participant Data.PMC11470871Fusetti CRizzardini GPetri FMerli SGori APasserini MGiorgi RMurad MHfalseNeurobrucellosis Presenting with Motor Damage or Hearing Loss, and Use of Steroids are Associated with a Higher Risk of Sequelae or Relapse: A Systematic Review of Individual Participant Data.<h4>Background</h4>Neurobrucellosis presents diverse clinical challenges and risks of long-term complications.<h4>Objective</h4>We aimed to assess the relationship between the duration of antibiotic therapy, clinical factors, and the outcome of neurobrucellosis with a case report combined with a systematic review of the literature.<h4>Methods</h4>We present a case of a 31 years-old man successfully treated at our Institution. We then searched Ovid MEDLINE, Embase and Scopus for articles that encompassed neurobrucellosis cases, duration of treatment, and outcome. The primary outcome was to assess an association between the duration of treatment and the risk of sequelae or relapses. Univariate, multivariate and sensitivity analysis were carried out to define which variables affect​ed​ the cl2024-01-01T00:00:00Z2024 Nov2025-04-04T00:34:02.665Z2025-04-04T00:34:02.665ZS-EPMC114708713885823710.1007/s10072-024-07621-6