biostudies-literatureDekker ENNCI NIH HHSThe Dutch Cancer SocietyZonMwznae244https://www.ebi.ac.uk/biostudies/studies/S-EPMC11472162biostudies-literatureUnknown111(10)<h4>Background</h4>Patients with localized (that is non-metastatic) pancreatic ductal adenocarcinoma with an inadequate response or toxicity to first-line chemotherapy may benefit from chemotherapy switch. The aim was to explore the available data on the use and effect of chemotherapy switch, as reported in the literature.<h4>Methods</h4>A systematic search was conducted in Embase, MEDLINE (Ovid), the Web of Science, Cochrane, and Google Scholar on 1 December 2023. The main outcomes were the proportion of patients who underwent chemotherapy switch and the carbohydrate antigen 19-9 response and resection, R0 resection, and ypN0 resection rates after chemotherapy switch. Data were pooled using a random-effects model.<h4>Results</h4>A total of five retrospective studies, representing 863 patiThe British journal of surgeryChemotherapy switch for localized pancreatic cancer: a systematic review and meta-analysis.PMC1147216213417P30 CA00874810140022010009Meddouch ADekker ENO'Kane GMWilmink JWQadan MGroot Koerkamp BO'Reilly EMBesselink MGHNarayan RRAhmami MAde Wilde RFVerkolf EMMGehrels AMvan Eijck CHJHoms MYVMostert BfalseChemotherapy switch for localized pancreatic cancer: a systematic review and meta-analysis.<h4>Background</h4>Patients with localized (that is non-metastatic) pancreatic ductal adenocarcinoma with an inadequate response or toxicity to first-line chemotherapy may benefit from chemotherapy switch. The aim was to explore the available data on the use and effect of chemotherapy switch, as reported in the literature.<h4>Methods</h4>A systematic search was conducted in Embase, MEDLINE (Ovid), the Web of Science, Cochrane, and Google Scholar on 1 December 2023. The main outcomes were the proportion of patients who underwent chemotherapy switch and the carbohydrate antigen 19-9 response and resection, R0 resection, and ypN0 resection rates after chemotherapy switch. Data were pooled using a random-effects model.<h4>Results</h4>A total of five retrospective studies, representing 863 pati2024-01-01T00:00:00Z2024 Oct2026-07-15T17:41:19.323Z2025-04-04T00:29:14.121ZS-EPMC114721623940000810.1093/bjs/znae244