biostudies-literatureEdwards NCUS National Institutes of HealthNICHD NIH HHSNCATS NIH HHSNIA NIH HHSfcae331https://www.ebi.ac.uk/biostudies/studies/S-EPMC11472828biostudies-literatureUnknown6(5)By age 40 years, over 90% of adults with Down syndrome have Alzheimer's disease pathology and most progress to dementia. Despite having few systemic vascular risk factors, individuals with Down syndrome have elevated cerebrovascular disease markers that track with the clinical progression of Alzheimer's disease, suggesting a role of cerebrovascular disease that is hypothesized to be mediated by inflammatory factors. This study examined the pathways through which small vessel cerebrovascular disease contributes to Alzheimer's disease-related pathophysiology and neurodegeneration in adults with Down syndrome. One hundred eighty-five participants from the Alzheimer's Biomarkers Consortium-Down Syndrome [mean (SD) age = 45.2 (9.3) years] with available MRI and plasma biomarker data were includBrain communicationsCerebrovascular disease is associated with Alzheimer's plasma biomarker concentrations in adults with Down syndrome.PMC11472828P50 AG008702UL1 TR002373UL1 TR001873UL1 TR002345P30 AG062421U54 HD087011RF1 AG079519UL1 TR001414P50 AG005681P50 HD105353U19 AG068054P50 AG005133F31 AG090091P30 AG066519P30 AG062715UL1 TR001857U24 AG021886P30 AG066462U01 AG051412P30 AG066444U01 AG051406U54 HD090256R00 AG065506Zhang FZaman SKlunk WEO'Bryant SSchupf NPetersen MEBrickman AMCheema ARosas HDNadkarni NDoran EWClare IVaradarajan BEdwards NCAlzheimer’s Biomarkers Consortium–Down Syndrome (ABC-DS) InvestigatorsGutierrez JHenson RHanden BLHonig LBirn RMReiman EKeator DLee JHSilverman WPPang DMapstone MAlshikho MJJanelidze SPrice JCChristian BTChen KFeingold EHansson OFagan ATudorascu DLParisi MEricsson OMIkonomovic MDKreisl WCBulova PWhite DAHead EPulsifer MPetersen MRizvi BSimoes SMathis CARyan LJordan CLai FWilcock DMAnces BMTycko BLott ITJohnson SCAizenstein HJLao PJConstantino JNCohen ADForoud TMHom CKrinsky-McHale SJMinhas DSHarp JAguilar LFRafii MSTumuluru RBell KLaymon CSchmitt FKofler JKHartley SLKamboh MILao PYassa MALupson VAndrews HFfalseCerebrovascular disease is associated with Alzheimer's plasma biomarker concentrations in adults with Down syndrome.By age 40 years, over 90% of adults with Down syndrome have Alzheimer's disease pathology and most progress to dementia. Despite having few systemic vascular risk factors, individuals with Down syndrome have elevated cerebrovascular disease markers that track with the clinical progression of Alzheimer's disease, suggesting a role of cerebrovascular disease that is hypothesized to be mediated by inflammatory factors. This study examined the pathways through which small vessel cerebrovascular disease contributes to Alzheimer's disease-related pathophysiology and neurodegeneration in adults with Down syndrome. One hundred eighty-five participants from the Alzheimer's Biomarkers Consortium-Down Syndrome [mean (SD) age = 45.2 (9.3) years] with available MRI and plasma biomarker data were includ2024-01-01T00:00:00Z20242026-07-09T10:29:48.931Z2025-04-04T02:22:31.371ZS-EPMC114728283940307510.1093/braincomms/fcae331