{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Yuan X"],"pubmed_abstract":["<h4>Introduction</h4>Knee osteoarthritis (KOA) is a chronic degenerative bone metabolic disease that primarily affects older adults, leading to chronic pain and disability that affect patients' daily activities. Electroacupuncture (EA) is a commonly used method for the treatment of chronic pain in clinical practice. Previous studies indicate that the endocannabinoid system is involved in EA analgesia, but whether endocannabinopeptide VD-hemopressin (α) and RVD-hemopressin (α) derived from hemoglobin chains are involved in EA analgesia is unclear.<h4>Methods</h4>RNA-seq technology was used to screen which genes involved in EA analgesia. The expression of hemoglobin α chain and 26S proteasome were determined by Western blotting. The level of VD-hemopressin (α) and RVD-hemopressin (α) were me"],"journal":["Frontiers in pharmacology"],"pagination":["1439448"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11473328"],"repository":["biostudies-literature"],"pubmed_title":["Hemoglobin α-derived peptides VD-hemopressin (α) and RVD-hemopressin (α) are involved in electroacupuncture inhibition of chronic pain."],"pmcid":["PMC11473328"],"pubmed_authors":["Baba SS","Yi H","Guo Y","Huo F","Jia H","Yuan X","Hou X","Wang Y","Zhao Y","Li M"],"additional_accession":[]},"is_claimable":false,"name":"Hemoglobin α-derived peptides VD-hemopressin (α) and RVD-hemopressin (α) are involved in electroacupuncture inhibition of chronic pain.","description":"<h4>Introduction</h4>Knee osteoarthritis (KOA) is a chronic degenerative bone metabolic disease that primarily affects older adults, leading to chronic pain and disability that affect patients' daily activities. Electroacupuncture (EA) is a commonly used method for the treatment of chronic pain in clinical practice. Previous studies indicate that the endocannabinoid system is involved in EA analgesia, but whether endocannabinopeptide VD-hemopressin (α) and RVD-hemopressin (α) derived from hemoglobin chains are involved in EA analgesia is unclear.<h4>Methods</h4>RNA-seq technology was used to screen which genes involved in EA analgesia. The expression of hemoglobin α chain and 26S proteasome were determined by Western blotting. The level of VD-hemopressin (α) and RVD-hemopressin (α) were me","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-04T13:53:35.985Z","creation":"2025-04-04T13:53:35.985Z"},"accession":"S-EPMC11473328","cross_references":{"pubmed":["39411061"],"doi":["10.3389/fphar.2024.1439448"]}}