{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bartos LM"],"funding":["Deutsche Forschungsgemeinschaft (DFG)","Deutsche Forschungsgemeinschaft"],"pagination":["4618-4634"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11474166"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(20)"],"pubmed_abstract":["Purpose
Current therapy strategies still provide only limited success in the treatment of glioblastoma, the most frequent primary brain tumor in adults. In addition to the characterization of the tumor microenvironment, global changes in the brain of patients with glioblastoma have been described. However, the impact and molecular signature of neuroinflammation distant of the primary tumor site have not yet been thoroughly elucidated.Experimental design
We performed translocator protein (TSPO)-PET in patients with newly diagnosed glioblastoma (n = 41), astrocytoma WHO grade 2 (n = 7), and healthy controls (n = 20) and compared TSPO-PET signals of the non-lesion (i.e., contralateral) hemisphere. Back-translation into syngeneic SB28 glioblastoma mice was used to characterize "],"journal":["Clinical cancer research : an official journal of the American Association for Cancer Research"],"pubmed_title":["Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome."],"pmcid":["PMC11474166"],"funding_grant_id":["421887978 and 422188432","EXC 2145 SyNergy – ID 390857198","EXC 2145 SyNergy - ID 390857198","403161218"],"pubmed_authors":["Wind-Mark K","Hartel M","Kolabas ZI","Franzmeier N","Blobner J","Ruf VC","Rauchmann BS","Perneczky R","Zenatti V","Kirchleitner SV","Herms J","Zounek A","Albert NL","Brendel M","Holzgreve A","Kaiser L","Ziegler S","Zatcepin A","Park HE","Thon N","Kunze LH","Erturk A","Tonn JC","Groß M","Hoermann L","Quach S","Stocklein S","Prestel M","von Baumgarten L","Ulukaya S","Kunte ST","Riemenschneider MJ","Bartos LM","Tahirovic S"],"additional_accession":[]},"is_claimable":false,"name":"Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome.","description":"Purpose
Current therapy strategies still provide only limited success in the treatment of glioblastoma, the most frequent primary brain tumor in adults. In addition to the characterization of the tumor microenvironment, global changes in the brain of patients with glioblastoma have been described. However, the impact and molecular signature of neuroinflammation distant of the primary tumor site have not yet been thoroughly elucidated.Experimental design
We performed translocator protein (TSPO)-PET in patients with newly diagnosed glioblastoma (n = 41), astrocytoma WHO grade 2 (n = 7), and healthy controls (n = 20) and compared TSPO-PET signals of the non-lesion (i.e., contralateral) hemisphere. Back-translation into syngeneic SB28 glioblastoma mice was used to characterize ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-07T08:11:00.157Z","creation":"2025-04-05T23:44:43.399Z"},"accession":"S-EPMC11474166","cross_references":{"pubmed":["39150564"],"doi":["10.1158/1078-0432.CCR-24-1563"]}}