biostudies-literatureJongkhajornpong PMedical Council of ThailandFaculty of Medicine, Ramathibodi Hospital, Mahidol Universitye001857https://www.ebi.ac.uk/biostudies/studies/S-EPMC11474780biostudies-literatureUnknown9(1)<h4>Objective</h4>The 0bjective is to compare treatment effects between undiluted autologous platelet-rich plasma (APRP) and autologous serum (AS) in patients with moderate-to-severe dry eye disease (DED).<h4>Methods and analysis</h4>A single-centre, randomised, double-masked, non-inferiority clinical trial was conducted. 96 adult DED patients with an Ocular Surface Disease Index (OSDI) Score of ≥23 and/or Oxford staining grade of ≥2 were randomised to receive either 100% APRP (n=48) or 100% AS (n=48) for 4 weeks. Primary outcomes included OSDI Score and ocular surface staining measured by Oxford grading scale at 4 weeks. Secondary outcomes included fluorescein tear break-up time, Schirmer's test, meibum quality and expressibility, and adverse events. The 95% CI for the mean difference in BMJ open ophthalmologyEfficacy of 100% autologous platelet-rich plasma and 100% autologous serum in dry eye disease: a randomised controlled trial.PMC11474780640042021Rattanasiri SThakkinstian AJongkhajornpong PAttia JLekhanont KMcKay GNumthavaj PfalseEfficacy of 100% autologous platelet-rich plasma and 100% autologous serum in dry eye disease: a randomised controlled trial.<h4>Objective</h4>The 0bjective is to compare treatment effects between undiluted autologous platelet-rich plasma (APRP) and autologous serum (AS) in patients with moderate-to-severe dry eye disease (DED).<h4>Methods and analysis</h4>A single-centre, randomised, double-masked, non-inferiority clinical trial was conducted. 96 adult DED patients with an Ocular Surface Disease Index (OSDI) Score of ≥23 and/or Oxford staining grade of ≥2 were randomised to receive either 100% APRP (n=48) or 100% AS (n=48) for 4 weeks. Primary outcomes included OSDI Score and ocular surface staining measured by Oxford grading scale at 4 weeks. Secondary outcomes included fluorescein tear break-up time, Schirmer's test, meibum quality and expressibility, and adverse events. The 95% CI for the mean difference in 2024-01-01T00:00:00Z2024 Oct2026-06-02T03:58:07.472Z2025-04-04T11:05:39.07ZS-EPMC114747803938422210.1136/bmjophth-2024-001857