{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Xu J"],"funding":["Natural Science Foundation of Hunan Province","National Natural Science Foundation of China","Nanhu Scholars Program for Young Scholars of Xinyang Normal University","Xinyang Normal University"],"pubmed_abstract":["A bidirectional self-powered biosensor is constructed for the quasi-simultaneous detection of Pb<sup>2+</sup> and Hg<sup>2+</sup> based on MoS<sub>2</sub>@CuS heterostructures as an accelerator and hybridization chain reaction (HCR) as a signal amplification strategy. MoS<sub>2</sub>@CuS heterostructures significantly facilitate electron transfer between glucose and bioelectrodes, thereby greatly improving the detection signal of self-powered biosensors. This novel biosensor employs the unique sequences of DNAzymes to isolate Pb<sup>2+</sup> and Hg<sup>2+</sup> by the cleavage effect and thymine (T)-Hg<sup>2+</sup>-thymine (T) structures, respectively. In the process, Pb<sup>2+</sup> cuts the sequence of DNAzyme at the bioanode to trigger glucose oxidation to monitor Pb<sup>2+</sup>. The a"],"journal":["Chemical science"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11474792"],"repository":["biostudies-literature"],"pubmed_title":["On-demand controlled bidirectional DNAzyme path for ultra-sensitive heavy metal ion detection."],"pmcid":["PMC11474792"],"funding_grant_id":["2021JJ20020","22004032","2024JJ5348"],"pubmed_authors":["Zhang W","Yang H","Cai R","Li Y","Tan W","Lyu Y","Wang F","Luo X","Xu J"],"additional_accession":[]},"is_claimable":false,"name":"On-demand controlled bidirectional DNAzyme path for ultra-sensitive heavy metal ion detection.","description":"A bidirectional self-powered biosensor is constructed for the quasi-simultaneous detection of Pb<sup>2+</sup> and Hg<sup>2+</sup> based on MoS<sub>2</sub>@CuS heterostructures as an accelerator and hybridization chain reaction (HCR) as a signal amplification strategy. MoS<sub>2</sub>@CuS heterostructures significantly facilitate electron transfer between glucose and bioelectrodes, thereby greatly improving the detection signal of self-powered biosensors. This novel biosensor employs the unique sequences of DNAzymes to isolate Pb<sup>2+</sup> and Hg<sup>2+</sup> by the cleavage effect and thymine (T)-Hg<sup>2+</sup>-thymine (T) structures, respectively. In the process, Pb<sup>2+</sup> cuts the sequence of DNAzyme at the bioanode to trigger glucose oxidation to monitor Pb<sup>2+</sup>. The a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T00:08:31.492Z","creation":"2025-04-04T00:08:31.492Z"},"accession":"S-EPMC11474792","cross_references":{"pubmed":["39421206"],"doi":["10.1039/d4sc04404e"]}}