biostudies-literatureWang Hthe 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan Universitythe National Natural Science Foundation of China225https://www.ebi.ac.uk/biostudies/studies/S-EPMC11476089biostudies-literatureUnknown16(1)<h4>Background</h4>Multiple psychosocial factors have been associated with dementia, while the individual or joint effects of various psychosocial states on dementia remain unrevealed due to the complex interplay between those factors. Here, the authors examined the associations of psychosocial factors and patterns with subsequent risk of dementia, and if the associations could be modified by genetic susceptibility to dementia.<h4>Methods</h4>UK Biobank dementia-free participants were followed from one year after recruitment (median date: 24 January, 2010) until 31 October, 2022. Psychosocial states were measured by 22 items related to five dimensions, including psychiatric history, recent stressful life events, current psychiatric symptoms, social contact, and individual socioeconomic staAlzheimer's research & therapyAssociation of psychosocial state with subsequent risk of dementia: a prospective cohort study based on the UK Biobank.PMC11476089ZYYC2100582402390Yang HShen QChen WWang HZeng YSong HWang JfalseAssociation of psychosocial state with subsequent risk of dementia: a prospective cohort study based on the UK Biobank.<h4>Background</h4>Multiple psychosocial factors have been associated with dementia, while the individual or joint effects of various psychosocial states on dementia remain unrevealed due to the complex interplay between those factors. Here, the authors examined the associations of psychosocial factors and patterns with subsequent risk of dementia, and if the associations could be modified by genetic susceptibility to dementia.<h4>Methods</h4>UK Biobank dementia-free participants were followed from one year after recruitment (median date: 24 January, 2010) until 31 October, 2022. Psychosocial states were measured by 22 items related to five dimensions, including psychiatric history, recent stressful life events, current psychiatric symptoms, social contact, and individual socioeconomic sta2024-01-01T00:00:00Z2024 Oct2026-07-15T09:33:02.807Z2025-04-04T01:25:16.342ZS-EPMC114760893940722410.1186/s13195-024-01592-8