biostudies-literatureUnknown25(19)D'Angelo CMicrobial biofilm formation on medical devices paves the way for device-associated infections. <i>Staphylococcus epidermidis</i> is one of the most common strains involved in such infections as it is able to colonize numerous devices, such as intravenous catheters, prosthetic joints, and heart valves. We previously reported the antibiofilm activity against <i>S. epidermidis</i> of pentadecanoic acid (PDA) deposited by drop-casting on the silicon-based polymer poly(dimethyl)siloxane (PDMS). This material exerted an antibiofilm activity by releasing PDA; however, a toxic effect on bacterial cells was observed, which could potentially favor the emergence of resistant strains. To develop a PDA-functionalized material for medical use and overcome the problem of toxicity, we produced PDA-doped PInternational journal of molecular sciences10727https://www.ebi.ac.uk/biostudies/studies/S-EPMC11476977biostudies-literaturePentadecanoic Acid-Releasing PDMS: Towards a New Material to Prevent &lt;i&gt;S. epidermidis&lt;/i&gt; Biofilm Formation.PMC11476977Faggiano SViale ECasillo ATutino MLD'Angelo CCorsaro MMParrilli EBettati SOlimpo DImbimbo PMonti DMRonda LfalsePentadecanoic Acid-Releasing PDMS: Towards a New Material to Prevent &lt;i&gt;S. epidermidis&lt;/i&gt; Biofilm Formation.Microbial biofilm formation on medical devices paves the way for device-associated infections. <i>Staphylococcus epidermidis</i> is one of the most common strains involved in such infections as it is able to colonize numerous devices, such as intravenous catheters, prosthetic joints, and heart valves. We previously reported the antibiofilm activity against <i>S. epidermidis</i> of pentadecanoic acid (PDA) deposited by drop-casting on the silicon-based polymer poly(dimethyl)siloxane (PDMS). This material exerted an antibiofilm activity by releasing PDA; however, a toxic effect on bacterial cells was observed, which could potentially favor the emergence of resistant strains. To develop a PDA-functionalized material for medical use and overcome the problem of toxicity, we produced PDA-doped P2024-01-01T00:00:00Z2024 Oct2025-04-04T01:17:17.477Z2025-04-04T01:17:17.477ZS-EPMC114769773940905610.3390/ijms251910727