biostudies-literatureFan JNatural Science Foundation of Henan ProvinceNational Natural Science Foundation of China10542https://www.ebi.ac.uk/biostudies/studies/S-EPMC11477159biostudies-literatureUnknown25(19)Since Teleostei fins have a strong regenerative capacity, further research was conducted on the regulation of gene expression during fin regeneration. This research focuses on miRNA, which is a key post-transcriptional regulatory molecule. In this study, a miRNA library for the fin regeneration of zebrafish was constructed to reveal the differential expression of miRNA during fin regeneration and to explore the regulatory pathway for fin regeneration. Following the injection of miRNA agomir into zebrafish, the proliferation of blastema cells and the overall fin regeneration area were significantly reduced. It was observed that the miRNAs impaired blastocyte formation by affecting fin regeneration through the inhibition of the expressions of genes and proteins associated with blastocyte forInternational journal of molecular sciencesThe Regulatory Role of miRNAs in Zebrafish Fin Regeneration.PMC11477159U1404330202300410243Liu XDuan ZFan JChang ZLi LZhao HfalseThe Regulatory Role of miRNAs in Zebrafish Fin Regeneration.Since Teleostei fins have a strong regenerative capacity, further research was conducted on the regulation of gene expression during fin regeneration. This research focuses on miRNA, which is a key post-transcriptional regulatory molecule. In this study, a miRNA library for the fin regeneration of zebrafish was constructed to reveal the differential expression of miRNA during fin regeneration and to explore the regulatory pathway for fin regeneration. Following the injection of miRNA agomir into zebrafish, the proliferation of blastema cells and the overall fin regeneration area were significantly reduced. It was observed that the miRNAs impaired blastocyte formation by affecting fin regeneration through the inhibition of the expressions of genes and proteins associated with blastocyte for2024-01-01T00:00:00Z2024 Sep2026-07-06T03:17:39.736Z2025-04-04T07:40:36.535ZS-EPMC114771593940886910.3390/ijms251910542