biostudies-literatureDominguez-Berzosa LInstituto de Salud Carlos IIIMinisterio de Ciencia, Innovación y Universidades10705https://www.ebi.ac.uk/biostudies/studies/S-EPMC11477271biostudies-literatureUnknown25(19)The <i>Taq</i>IA polymorphism is a marker of both the Ankyrin Repeat and Kinase Domain containing I gene (<i>ANKK1</i>) encoding a RIP-kinase, and the <i>DRD2</i> gene for the dopamine receptor D2. Despite a large number of studies of <i>Taq</i>IA in addictions and other psychiatric disorders, there is difficulty in interpreting this genetic phenomenon due to the lack of knowledge about ANKK1 function. In SH-SY5Y neuroblastoma models, we show that ANKK1 interacts with the synapse protein FERM ARH/RhoGEF and Pleckstrin Domain 1 (FARP1), which is a guanine nucleotide exchange factor (GEF) of the RhoGTPases RAC1 and RhoA. ANKK1-FARP1 colocalized in F-ACTIN-rich structures for neuronal maturation and migration, and both proteins activate the Wnt/PCP pathway. ANKK1, but not FARP1, promotes neurInternational journal of molecular sciencesANKK1 Is a Wnt/PCP Scaffold Protein for Neural F-ACTIN Assembly.PMC11477271PI22/00680CEX2020-001041-SPI19/00126Hoenicka JLopez JATort GGarrido EPalau FRodriguez-Sanz MUrquizu ECantarero LDominguez-Berzosa LSaez MFernandez-Lizarbe SCastro-Martinez XHCalvo ETroya-Balseca JPalomo TfalseANKK1 Is a Wnt/PCP Scaffold Protein for Neural F-ACTIN Assembly.The <i>Taq</i>IA polymorphism is a marker of both the Ankyrin Repeat and Kinase Domain containing I gene (<i>ANKK1</i>) encoding a RIP-kinase, and the <i>DRD2</i> gene for the dopamine receptor D2. Despite a large number of studies of <i>Taq</i>IA in addictions and other psychiatric disorders, there is difficulty in interpreting this genetic phenomenon due to the lack of knowledge about ANKK1 function. In SH-SY5Y neuroblastoma models, we show that ANKK1 interacts with the synapse protein FERM ARH/RhoGEF and Pleckstrin Domain 1 (FARP1), which is a guanine nucleotide exchange factor (GEF) of the RhoGTPases RAC1 and RhoA. ANKK1-FARP1 colocalized in F-ACTIN-rich structures for neuronal maturation and migration, and both proteins activate the Wnt/PCP pathway. ANKK1, but not FARP1, promotes neur2024-01-01T00:00:00Z2024 Oct2026-07-05T03:16:49.269Z2025-04-04T23:50:12.326ZS-EPMC114772713940903510.3390/ijms251910705