{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(19)"],"submitter":["Watrowski R"],"pubmed_abstract":["Single nucleotide polymorphisms (SNPs) of the IL-16 gene have been reported to influence the risk of several cancers, but their role in ovarian cancer (OC) has not been studied. Using the restriction fragment length polymorphism (PCR-RFLP) method, we examined four IL-16 SNPs: rs11556218 (T > G), rs4778889 (T > C), rs4072111 (C > T), and rs1131445 (T > C) in blood samples from 413 women of Central European descent, including 200 OC patients and 213 healthy controls. Among the patients, 62% were postmenopausal, 84.5% were diagnosed in late stages (FIGO IIb-IV), and 73.5% had high-grade serous OC (HGSOC). Minor allele frequencies in controls were 9.2% for rs11556218 (G allele), 13.7% for rs4778889 (C allele), 10.4% for rs4072111 (T allele), and 32.3% for rs1131445 (C allele). We found signifi"],"journal":["International journal of molecular sciences"],"pagination":["10272"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11477281"],"repository":["biostudies-literature"],"pubmed_title":["Association of the Single Nucleotide Polymorphisms rs11556218, rs4778889, rs4072111, and rs1131445 of the Interleukin-16 Gene with Ovarian Cancer."],"pmcid":["PMC11477281"],"pubmed_authors":["Fischer MB","Watrowski R","Mahner S","Polterauer S","Schuster E","Zeillinger R","Hofstetter G","Van Gorp T","Obermayr E"],"additional_accession":[]},"is_claimable":false,"name":"Association of the Single Nucleotide Polymorphisms rs11556218, rs4778889, rs4072111, and rs1131445 of the Interleukin-16 Gene with Ovarian Cancer.","description":"Single nucleotide polymorphisms (SNPs) of the IL-16 gene have been reported to influence the risk of several cancers, but their role in ovarian cancer (OC) has not been studied. Using the restriction fragment length polymorphism (PCR-RFLP) method, we examined four IL-16 SNPs: rs11556218 (T > G), rs4778889 (T > C), rs4072111 (C > T), and rs1131445 (T > C) in blood samples from 413 women of Central European descent, including 200 OC patients and 213 healthy controls. Among the patients, 62% were postmenopausal, 84.5% were diagnosed in late stages (FIGO IIb-IV), and 73.5% had high-grade serous OC (HGSOC). Minor allele frequencies in controls were 9.2% for rs11556218 (G allele), 13.7% for rs4778889 (C allele), 10.4% for rs4072111 (T allele), and 32.3% for rs1131445 (C allele). We found signifi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-30T03:14:59.516Z","creation":"2026-06-29T03:08:31.989Z"},"accession":"S-EPMC11477281","cross_references":{"pubmed":["39408600"],"doi":["10.3390/ijms251910272"]}}