biostudies-literatureJesus AFundação para a Ciência e a TecnologiaFundação para a Ciência e Tecnologia4604https://www.ebi.ac.uk/biostudies/studies/S-EPMC11477482biostudies-literatureUnknown29(19)The pursuit of cosmetic ingredients with proven efficacy and safety that meet consumer needs drives the advancement of new products. Ascorbic acid (AA) is utilized in cosmetic products, predominantly for its potent antioxidant properties. Nonetheless, its instability compromises its efficacy. In this work, ascorbyl 2-<i>O</i>-glucoside persulfate (AAGS) was synthesized, characterized, and evaluated regarding its safety profile and potential bioactivities and the results were compared to AA and its glycoside AAG. Pre-formulation studies were performed to assess the stability of the compounds and their compatibility with typical excipients commonly used in topical formulations. AAGS did not affect the metabolic activity of keratinocyte, macrophage, and monocyte cell lines, up to 500 µM. AAGSMolecules (Basel, Switzerland)Persulfated Ascorbic Acid Glycoside as a Safe and Stable Derivative of Ascorbic Acid for Skin Care Application.PMC11477482in the scope of the project UIDP/04378/2020 (DOI: 10.54499/UIDP/04378/2020) and UIDB/04378/2020 (DOI: 10.54499/UIDB/04378/2020) of the Research Unit on Applied Molecular Biosciences-UCIBIO and the project LA/P/0140/2020 (DOI: 10.54499/LA/P/0140/2020) of tAna I. Sebastião acknowledges her Ph.D. grant with reference DOI: 10.54499/2021.04586.BDAna Jesus acknowledges her Ph.D. grant with reference UI/BD/151319/2021 with DOI: 10.54499/UI/BD/151319/2021the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under project CENTRO-01-0145-FEDER-000012 (HealthyAging2020)Gonçalo Brites acknowledges his Ph.D. grant with reference PD/BDE/142926/2018the projects UIDP/04539/2020, and UIDP/04423/2020 (Group of Marine Natural Products and Medicinal Chemistry-CIIMAR), and the projects UIDP/04539/2020 and LA/P/0058/2020 from CIBBCruz MTBrites GCarrascal MJesus ACidade HConfraria CSebastiao AIAlmeida IFSilva SCosta PCorreia-da-Silva MSousa EPinto MfalsePersulfated Ascorbic Acid Glycoside as a Safe and Stable Derivative of Ascorbic Acid for Skin Care Application.The pursuit of cosmetic ingredients with proven efficacy and safety that meet consumer needs drives the advancement of new products. Ascorbic acid (AA) is utilized in cosmetic products, predominantly for its potent antioxidant properties. Nonetheless, its instability compromises its efficacy. In this work, ascorbyl 2-<i>O</i>-glucoside persulfate (AAGS) was synthesized, characterized, and evaluated regarding its safety profile and potential bioactivities and the results were compared to AA and its glycoside AAG. Pre-formulation studies were performed to assess the stability of the compounds and their compatibility with typical excipients commonly used in topical formulations. AAGS did not affect the metabolic activity of keratinocyte, macrophage, and monocyte cell lines, up to 500 µM. AAGS2024-01-01T00:00:00Z2024 Sep2025-04-18T14:09:49.769Z2025-04-04T19:38:28.454ZS-EPMC114774823940753510.3390/molecules29194604