biostudies-literatureWang EProject of Natural Science Research of Guizhou Vocational College of AgricultureInnovation Capacity Construction of Scientific Research Institutions in Guizhou ProvinceGuizhou Provincial Natural Science FoundationProject of Key Laboratory for Characteristics of Colleges and Universities of Guizhou Provincial Department of Education4632https://www.ebi.ac.uk/biostudies/studies/S-EPMC11477491biostudies-literatureUnknown29(19)Cinnamides are common core structures that exist in a great number of pharmaceuticals and natural products. The development of efficient methods for preparing cinnamides is in great need. We report herein an efficient polyphosphoric acid (PPA)-promoted direct aldol condensation of an amide for the convenient and straightforward preparation of cinnamides. A variety of cinnamides were obtained in moderate-to-excellent yields (65-89%). This strategy features the use of equivalent amides and a short reaction time.Molecules (Basel, Switzerland)Polyphosphoric Acid-Promoted Efficient Synthesis of Cinnamides via Aldol Condensation of Amide.PMC11477491QKHFQ[2024]005QKHJC-ZK[2024] General 643QJHKYZ[2020]018yk230109Yang XLiu YYang LLei YWang EHe LYang QWang XLi MfalsePolyphosphoric Acid-Promoted Efficient Synthesis of Cinnamides via Aldol Condensation of Amide.Cinnamides are common core structures that exist in a great number of pharmaceuticals and natural products. The development of efficient methods for preparing cinnamides is in great need. We report herein an efficient polyphosphoric acid (PPA)-promoted direct aldol condensation of an amide for the convenient and straightforward preparation of cinnamides. A variety of cinnamides were obtained in moderate-to-excellent yields (65-89%). This strategy features the use of equivalent amides and a short reaction time.2024-01-01T00:00:00Z2024 Sep2025-04-04T11:03:57.079Z2025-04-04T11:03:57.079ZS-EPMC114774913940756110.3390/molecules29194632