{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou ZS"],"funding":["the High-level Talent Promotion and Training Project of Kunming","the Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform","National Natural Science Foundation of China"],"pagination":["4631"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11477649"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(19)"],"pubmed_abstract":["Three novel <i>ent</i>-kaurane diterpenes, namely sigesbeckin A-C (<b>1</b>-<b>3</b>), in conjunction with eight previously identified analogues (<b>4</b>-<b>11</b>), were isolated from <i>Sigesbeckia orientalis</i>. Their chemical structures were resolved through multiple spectroscopic analyses. All compounds were assessed for antimicrobial bioactivity against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and vancomycin-resistant <i>enterococci</i> (VRE) strains. In particular, compounds <b>1</b> and <b>5</b> demonstrated moderate efficacy, with MIC values of 64 μg/mL. Moreover, compounds <b>3</b>, <b>5</b>, and <b>11</b> were found to synergize with doxorubicin hydrochloride (DOX) and vancomycin (VAN) against MRSA and VRE. The aforementioned findings offer valuable insights for the development of novel alternatives to antibiotics, which can effectively tackle the escalating issue of antibiotic resistance."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Three New &lt;i&gt;Ent&lt;/i&gt;-Kaurane Diterpenes with Antibacterial Activity from &lt;i&gt;Sigesbeckia orientalis&lt;/i&gt;."],"pmcid":["PMC11477649"],"funding_grant_id":["32170405","2022SCP003","2022YKZY001"],"pubmed_authors":["Luo XD","Zhao YL","Wei MZ","Tian B","Zhu YY","Wang ZJ","Zhou ZS"],"additional_accession":[]},"is_claimable":false,"name":"Three New &lt;i&gt;Ent&lt;/i&gt;-Kaurane Diterpenes with Antibacterial Activity from &lt;i&gt;Sigesbeckia orientalis&lt;/i&gt;.","description":"Three novel <i>ent</i>-kaurane diterpenes, namely sigesbeckin A-C (<b>1</b>-<b>3</b>), in conjunction with eight previously identified analogues (<b>4</b>-<b>11</b>), were isolated from <i>Sigesbeckia orientalis</i>. Their chemical structures were resolved through multiple spectroscopic analyses. All compounds were assessed for antimicrobial bioactivity against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and vancomycin-resistant <i>enterococci</i> (VRE) strains. In particular, compounds <b>1</b> and <b>5</b> demonstrated moderate efficacy, with MIC values of 64 μg/mL. Moreover, compounds <b>3</b>, <b>5</b>, and <b>11</b> were found to synergize with doxorubicin hydrochloride (DOX) and vancomycin (VAN) against MRSA and VRE. The aforementioned findings offer valuable insights for the development of novel alternatives to antibiotics, which can effectively tackle the escalating issue of antibiotic resistance.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-04T02:19:32.491Z","creation":"2025-04-04T02:19:32.491Z"},"accession":"S-EPMC11477649","cross_references":{"pubmed":["39407562"],"doi":["10.3390/molecules29194631"]}}