{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Klein JA"],"funding":["NIAID NIH HHS","NIGMS NIH HHS"],"pagination":["e0031424"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11477908"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["92(10)"],"pubmed_abstract":["<i>Providencia alcalifaciens</i> is a Gram-negative bacterium found in various water and land environments and organisms, including insects and mammals. Some <i>P. alcalifaciens</i> strains encode gene homologs of virulence factors found in pathogenic Enterobacterales members, such as <i>Salmonella enterica</i> serovar Typhimurium and <i>Shigella flexneri</i>. Whether these genes are pathogenic determinants in <i>P. alcalifaciens</i> is not known. In this study, we investigated <i>P. alcalifaciens</i>-host interactions at the cellular level, focusing on the role of two type III secretion systems (T3SS) belonging to the Inv-Mxi/Spa family. T3SS<sub>1b</sub> is widespread in <i>Providencia</i> spp. and encoded on the chromosome. A large plasmid that is present in a subset of <i>P. alcalifaci"],"journal":["Infection and immunity"],"pubmed_title":["Pathogenic diversification of the gut commensal <i>Providencia alcalifaciens</i> via acquisition of a second type III secretion system."],"pmcid":["PMC11477908"],"funding_grant_id":["R21 AI130645","T32 GM140936","R01 AI134766"],"pubmed_authors":["Lele A","Klein JA","Predeus AV","Green NM","Cruz E","Mejia A","Goodman AG","Elfenbein JR","Clark-Herrera MM","Greissl AR","Wright SJ","Haeberle AL","Howell M","Knodler LA","Wrande M","Westerman TL","McClelland M","Vallance BA","Cundiff JA","Robinson DJ"],"additional_accession":[]},"is_claimable":false,"name":"Pathogenic diversification of the gut commensal <i>Providencia alcalifaciens</i> via acquisition of a second type III secretion system.","description":"<i>Providencia alcalifaciens</i> is a Gram-negative bacterium found in various water and land environments and organisms, including insects and mammals. Some <i>P. alcalifaciens</i> strains encode gene homologs of virulence factors found in pathogenic Enterobacterales members, such as <i>Salmonella enterica</i> serovar Typhimurium and <i>Shigella flexneri</i>. Whether these genes are pathogenic determinants in <i>P. alcalifaciens</i> is not known. In this study, we investigated <i>P. alcalifaciens</i>-host interactions at the cellular level, focusing on the role of two type III secretion systems (T3SS) belonging to the Inv-Mxi/Spa family. T3SS<sub>1b</sub> is widespread in <i>Providencia</i> spp. and encoded on the chromosome. A large plasmid that is present in a subset of <i>P. alcalifaci","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T12:57:34.424Z","creation":"2025-04-04T23:49:56.592Z"},"accession":"S-EPMC11477908","cross_references":{"pubmed":["39254346"],"doi":["10.1128/iai.00314-24"]}}