{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bridge H"],"funding":["Medical Research Foundation","NIHR Oxford Biomedical Research Centre","Fight for Sight UK","National Institute for Health Research (NIHR)","Blind Veterans","Royal Society","Wellcome Trust","College of Optometrists","Esme’s Umbrella"],"pagination":["25158414241280201"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11481065"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16"],"pubmed_abstract":["<h4>Background</h4>Charles Bonnet syndrome (CBS) is a condition in which people with vision loss experience complex visual hallucinations. These complex visual hallucinations may be caused by increased excitability in the visual cortex that are present in some people with vision loss but not others.<h4>Objectives</h4>We aimed to evaluate the association between γ-aminobutyric acid (GABA) in the visual cortex and CBS. We also tested the relationship among visually evoked responses, functional connectivity, and CBS.<h4>Design</h4>This is a prospective, case-controlled, cross-sectional observational study.<h4>Methods</h4>We applied 3-Tesla magnetic resonance spectroscopy, as well as task-based and resting state (RS) connectivity functional magnetic resonance imaging in six participants with C"],"journal":["Therapeutic advances in ophthalmology"],"pubmed_title":["Neurochemistry and functional connectivity in the brain of people with Charles Bonnet syndrome."],"pmcid":["PMC11481065"],"funding_grant_id":["203139/Z/16/Z","Dorothy Hodgkin Research Fellowship","225924/Z/22/Z","portfolio funding","24BV20","MR/V034723/1","203139/A/16/Z","NIHR203316"],"pubmed_authors":["Rand B","Jolly JK","Bridge H","Starling L","Millington-Truby RS","Clarke WT","Wyllie A","Kay A","Ip IB"],"additional_accession":[]},"is_claimable":false,"name":"Neurochemistry and functional connectivity in the brain of people with Charles Bonnet syndrome.","description":"<h4>Background</h4>Charles Bonnet syndrome (CBS) is a condition in which people with vision loss experience complex visual hallucinations. These complex visual hallucinations may be caused by increased excitability in the visual cortex that are present in some people with vision loss but not others.<h4>Objectives</h4>We aimed to evaluate the association between γ-aminobutyric acid (GABA) in the visual cortex and CBS. We also tested the relationship among visually evoked responses, functional connectivity, and CBS.<h4>Design</h4>This is a prospective, case-controlled, cross-sectional observational study.<h4>Methods</h4>We applied 3-Tesla magnetic resonance spectroscopy, as well as task-based and resting state (RS) connectivity functional magnetic resonance imaging in six participants with C","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan-Dec","modification":"2025-04-22T10:56:48.501Z","creation":"2025-04-05T23:45:59.075Z"},"accession":"S-EPMC11481065","cross_references":{"pubmed":["39416975"],"doi":["10.1177/25158414241280201"]}}