{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(10)"],"submitter":["Natarajan R"],"pubmed_abstract":["We measured the average group refractive index (RI) of 120 isolated lenses from 120 human donors (age: 0.03 to 61 years). The average group RI was calculated from a measurement of the optical thickness of the lens using optical coherence tomography and the apparent window shift of the test chamber caused by the lens. The estimated measurement uncertainty was ±0.004. The group RI at 880 nm was converted to phase RI at 589 nm using the dispersion equation of water and protein. From 2 to 61 years, the mean value of the RI was 1.415 ± 0.002 (group index at 880 nm) and 1.406 ± 0.002 (phase index at 589 nm) independent of age (p = 0.774). Two lenses from donors of age 0.33 and 3 months had significantly lower RI (group index: 1.405 and 1.403; phase index: 1.396 and 1.394). From age 2 to 61, the "],"journal":["Biomedical optics express"],"pagination":["5901-5911"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11482174"],"repository":["biostudies-literature"],"pubmed_title":["Age dependence of the average refractive index of the isolated human crystalline lens."],"pmcid":["PMC11482174"],"pubmed_authors":["Manns F","Augusteyn R","Ruggeri M","Parel JM","Maceo Heilman B","Ho A","Natarajan R","Singh VM","Vaddavalli PK"],"additional_accession":[]},"is_claimable":false,"name":"Age dependence of the average refractive index of the isolated human crystalline lens.","description":"We measured the average group refractive index (RI) of 120 isolated lenses from 120 human donors (age: 0.03 to 61 years). The average group RI was calculated from a measurement of the optical thickness of the lens using optical coherence tomography and the apparent window shift of the test chamber caused by the lens. The estimated measurement uncertainty was ±0.004. The group RI at 880 nm was converted to phase RI at 589 nm using the dispersion equation of water and protein. From 2 to 61 years, the mean value of the RI was 1.415 ± 0.002 (group index at 880 nm) and 1.406 ± 0.002 (phase index at 589 nm) independent of age (p = 0.774). Two lenses from donors of age 0.33 and 3 months had significantly lower RI (group index: 1.405 and 1.403; phase index: 1.396 and 1.394). From age 2 to 61, the ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-14T03:17:46.447Z","creation":"2026-06-14T03:08:56.404Z"},"accession":"S-EPMC11482174","cross_references":{"pubmed":["39421764"],"doi":["10.1364/BOE.536501"]}}