{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Osaki T"],"funding":["NIMH NIH HHS","NINDS NIH HHS"],"pubmed_abstract":["Rett syndrome (RTT) is a neurodevelopmental disorder that is caused by mutations in melty-CpG binding protein 2 (MeCP2). MeCP2 is a non-cell type-specific DNA binding protein, and its mutation influences not only neural cells but also non-neural cells in the brain, including vasculature associated with endothelial cells. Vascular integrity is crucial for maintaining brain homeostasis, and its alteration may be linked to the pathology of neurodegenerative disease, but a non-neurogenic effect, especially the relationship between vascular alternation and Rett syndrome pathogenesis, has not been shown. Here, we recapitulate a microvascular network using Rett syndrome patient-derived induced pluripotent stem (iPS) cells that carry MeCP2[R306C] mutation to investigate early developmental vascula"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.10.11.617929"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11482880"],"repository":["biostudies-literature"],"pubmed_title":["miR126-mediated impaired vascular integrity in Rett syndrome."],"pmcid":["PMC11482880"],"funding_grant_id":["R01 MH133066","R01 MH085802","R01 NS130361"],"pubmed_authors":["Campisi M","Sur M","Wan Z","Jin Y","Osaki T","Kamm R","Haratani K","Barbie DA"],"additional_accession":[]},"is_claimable":false,"name":"miR126-mediated impaired vascular integrity in Rett syndrome.","description":"Rett syndrome (RTT) is a neurodevelopmental disorder that is caused by mutations in melty-CpG binding protein 2 (MeCP2). MeCP2 is a non-cell type-specific DNA binding protein, and its mutation influences not only neural cells but also non-neural cells in the brain, including vasculature associated with endothelial cells. Vascular integrity is crucial for maintaining brain homeostasis, and its alteration may be linked to the pathology of neurodegenerative disease, but a non-neurogenic effect, especially the relationship between vascular alternation and Rett syndrome pathogenesis, has not been shown. Here, we recapitulate a microvascular network using Rett syndrome patient-derived induced pluripotent stem (iPS) cells that carry MeCP2[R306C] mutation to investigate early developmental vascula","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-09T12:19:45.952Z","creation":"2025-04-03T23:51:08.379Z"},"accession":"S-EPMC11482880","cross_references":{"pubmed":["39415995"],"doi":["10.1101/2024.10.11.617929"]}}