{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Suarez-Pajes E"],"funding":["Ministerio de Ciencia e Innovación co-financed by the European Regional Development Funds (ERDF), \"A way of making Europe\" from the EU","Grupo DISA","Instituto de Salud Carlos III","Cabildo Insular de Tenerife","ITER","Agencia Canaria de Investigación, Innovación y Sociedad de la Información de la Consejería de Economía, Conocimiento y Empleo y por el Fondo Social Europeo (FSE) Programa Operativo Integrado de Canarias 2014-2020, Eje 3 Tema Prioritario 74 (85%)","Fundación Canaria Instituto de Investigación Sanitaria de Canarias"],"pagination":["374"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11484206"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["<h4>Background</h4>Community-acquired pneumonia (CAP) is associated with high morbidity and hospitalization rate. In infectious diseases, host genetics plays a critical role in susceptibility and immune response, and the immune pathways involved are highly dependent on the microorganism and its route of infection. Here we aimed to identify genetic risk loci for CAP using a case-control genome-wide association study (GWAS).<h4>Methods</h4>We performed a GWAS on 3,765 Spanish individuals, including 257 adult patients hospitalized with CAP and 3,508 population controls. Pneumococcal CAP was documented in 30% of patients; the remaining 70% were selected among patients with unidentified microbiological etiology. We tested 7,6 million imputed genotypes using logistic regressions. UK Biobank GWAS"],"journal":["Respiratory research"],"pubmed_title":["A genome-wide association study of adults with community-acquired pneumonia."],"pmcid":["PMC11484206"],"funding_grant_id":["CGIEU0000219140","PI17/00610","RTC-2017-6471-1; AEI/FEDER","TESIS2021010046","TESIS2022010042","PIFIISC19/43","OA18/017","OA17/008","PI13/01456"],"pubmed_authors":["Tosco-Herrera E","Lorente L","Valencia-Gallardo JM","Carbonell N","Lorenzo Salazar JM","Ramirez-Falcon M","Briones ML","Flores C","Borderias L","Freixinet JL","Hernandez Brito E","Sole Violan J","Rajas O","Ferreres J","Rodriguez de Castro F","Marcelino-Rodriguez I","Rubio-Rodriguez LA","Gonzalez-Barbuzano S","Payeras A","Suarez-Pajes E","Aspa J","Rodriguez-Gallego C"],"additional_accession":[]},"is_claimable":false,"name":"A genome-wide association study of adults with community-acquired pneumonia.","description":"<h4>Background</h4>Community-acquired pneumonia (CAP) is associated with high morbidity and hospitalization rate. In infectious diseases, host genetics plays a critical role in susceptibility and immune response, and the immune pathways involved are highly dependent on the microorganism and its route of infection. Here we aimed to identify genetic risk loci for CAP using a case-control genome-wide association study (GWAS).<h4>Methods</h4>We performed a GWAS on 3,765 Spanish individuals, including 257 adult patients hospitalized with CAP and 3,508 population controls. Pneumococcal CAP was documented in 30% of patients; the remaining 70% were selected among patients with unidentified microbiological etiology. We tested 7,6 million imputed genotypes using logistic regressions. UK Biobank GWAS","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T04:53:52.618Z","creation":"2025-04-04T09:58:42.05Z"},"accession":"S-EPMC11484206","cross_references":{"pubmed":["39415140"],"doi":["10.1186/s12931-024-03009-4"]}}