{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(38)"],"submitter":["van Leeuwen LP"],"pubmed_abstract":["In response to the mpox outbreak in 2022 and 2023, widespread vaccination with modified vaccinia Ankara-Bavarian Nordic (MVA-BN, also known as JYNNEOS or Imvanex) was initiated. Here, we demonstrate that orthopoxvirus-specific binding and MVA-neutralising antibodies waned to undetectable levels 1 year post vaccination in at-risk individuals who received two doses of MVA-BN administered subcutaneously with an interval of 4 weeks, without prior smallpox or mpox vaccination. Continuous surveillance is essential to understand the impact of declining antibody levels."],"journal":["Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11484288"],"repository":["biostudies-literature"],"pubmed_title":["Orthopoxvirus-specific antibodies wane to undetectable levels 1 year after MVA-BN vaccination of at-risk individuals, the Netherlands, 2022 to 2023."],"pmcid":["PMC11484288"],"pubmed_authors":["GeurtsvanKessel CH","Schmitz KS","Akhiyate N","van Royen ME","Shamier MC","Gotz HM","Wijnans K","Verstrepen BE","de Vries RD","van Leeuwen LP","van Gorp EC","Bogers S","Zaeck LM","Koopmans MP"],"additional_accession":[]},"is_claimable":false,"name":"Orthopoxvirus-specific antibodies wane to undetectable levels 1 year after MVA-BN vaccination of at-risk individuals, the Netherlands, 2022 to 2023.","description":"In response to the mpox outbreak in 2022 and 2023, widespread vaccination with modified vaccinia Ankara-Bavarian Nordic (MVA-BN, also known as JYNNEOS or Imvanex) was initiated. Here, we demonstrate that orthopoxvirus-specific binding and MVA-neutralising antibodies waned to undetectable levels 1 year post vaccination in at-risk individuals who received two doses of MVA-BN administered subcutaneously with an interval of 4 weeks, without prior smallpox or mpox vaccination. Continuous surveillance is essential to understand the impact of declining antibody levels.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-04T19:45:34.229Z","creation":"2025-04-04T19:45:34.229Z"},"accession":"S-EPMC11484288","cross_references":{"pubmed":["39301741"],"doi":["10.2807/1560-7917.ES.2024.29.38.2400575"]}}