biostudies-literatureUnknown13(9)Zhou Y<h4>Background</h4>Lung cancer is a globally prevailing malignancy, and the predominant histological subtype is lung adenocarcinoma (LUAD). IL-1 receptor-associated kinase 3 (<i>IRAK3</i>) has been identified in connection with innate immune and inflammatory response. The aim of this study is to investigate the impact of <i>IRAK3</i> on prognosis and immunotherapy efficacy in LUAD, which remains incompletely elucidated.<h4>Methods</h4>Our study delved into multiple online databases to find out expression, methylation and prognostic potentials of <i>IRAK3</i> in LUAD and other malignancies. We employed tissue microarrays to assess IRAK3 protein levels in our LUAD cohort [National Cancer Center (NCC), China] and explore prognostic values. The correlations between <i>IRAK3</i> and immune infiTranslational lung cancer research2139-2161https://www.ebi.ac.uk/biostudies/studies/S-EPMC11484737biostudies-literatureIL-1 receptor-associated kinase 3 (IRAK3) in lung adenocarcinoma predicts prognosis and immunotherapy resistance: involvement of multiple inflammation-related pathways.PMC11484737Shao FLi ZZhang ZHe JRao WGuo WZhang HXue QTan FZhou YLiu TGao SfalseIL-1 receptor-associated kinase 3 (IRAK3) in lung adenocarcinoma predicts prognosis and immunotherapy resistance: involvement of multiple inflammation-related pathways.<h4>Background</h4>Lung cancer is a globally prevailing malignancy, and the predominant histological subtype is lung adenocarcinoma (LUAD). IL-1 receptor-associated kinase 3 (<i>IRAK3</i>) has been identified in connection with innate immune and inflammatory response. The aim of this study is to investigate the impact of <i>IRAK3</i> on prognosis and immunotherapy efficacy in LUAD, which remains incompletely elucidated.<h4>Methods</h4>Our study delved into multiple online databases to find out expression, methylation and prognostic potentials of <i>IRAK3</i> in LUAD and other malignancies. We employed tissue microarrays to assess IRAK3 protein levels in our LUAD cohort [National Cancer Center (NCC), China] and explore prognostic values. The correlations between <i>IRAK3</i> and immune infi2024-01-01T00:00:00Z2024 Sep2026-07-15T12:58:04.607Z2025-04-04T22:48:04.973ZS-EPMC114847373943033810.21037/tlcr-24-391