{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Reddy JS"],"funding":["National Institute of Neurological Disorders and Stroke","Mayo Foundation for Medical Education and Research","NIA NIH HHS","Alzheimer's Association Zenith Fellows Award","National Brain and Tissue Resource for Parkinson's Disease and Related Disorders","Michael J. Fox Foundation for Parkinson's Research","National Institute on Aging","CurePSP Foundation","Arizona Biomedical Research Commission","Mayo Foundation","NINDS NIH HHS","Arizona Department of Health Services","Michael J. Fox Foundation for Parkinson&apos;s Research"],"pagination":["7174-7192"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11485084"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(10)"],"pubmed_abstract":["<h4>Introduction</h4>Multi-omics studies in Alzheimer's disease (AD) revealed many potential disease pathways and therapeutic targets. Despite their promise of precision medicine, these studies lacked Black Americans (BA) and Latin Americans (LA), who are disproportionately affected by AD.<h4>Methods</h4>To bridge this gap, Accelerating Medicines Partnership in Alzheimer's Disease (AMP-AD) expanded brain multi-omics profiling to multi-ethnic donors.<h4>Results</h4>We generated multi-omics data and curated and harmonized phenotypic data from BA (n = 306), LA (n = 326), or BA and LA (n = 4) brain donors plus non-Hispanic White (n = 252) and other (n = 20) ethnic groups, to establish a foundational dataset enriched for BA and LA participants. This study describes the data available to the res"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Bridging the gap: Multi-omics profiling of brain tissue in Alzheimer's disease and older controls in multi-ethnic populations."],"pmcid":["PMC11485084"],"funding_grant_id":["P01AG066597","U01 AG061357","P50 AG025711","U01 AG006786","R01 AG072474","U01 AG046139","U01AG061357","P30 AG072980","RF1AG062181","R01 AG032990","U24 NS072026","P30 AG072975","P30 AG019610","P30 AG072972","R01 AG022018","P30AG066511","P30 AG072979","R01‐NS080820","P30AG072980","R01 AG072120","U19AG062418","U01 AG006576","RF1 AG062181","P01 AG017216","U24 AG061340","R01 AG018023","P01 AG003949","R01 AG003949","U19 AG074879","U01 AG088425","U19 AG062418","P50 AG016574","R01 AG017216","P30 AG066511","R01 AG075827","R01 AG061796","R01 AG025711","R01 NS080820","P01 AG066597","R01 AG079170","R01-NS080820","P30AG072979"],"pubmed_authors":["Dickson DW","Duong DM","Lopes KP","Wang E","Carrasquillo MM","Seyfried NT","Shantaraman A","Chen X","De Jager P","Wang Y","Zhang B","Xu K","Heath L","Reddy H","Ho C","Greenwood AK","Reddy JS","Prokop S","Haroutunian V","Lah JJ","Lee EB","Ertekin-Taner N","Ping L","Barnes LL","Ma Y","Teich AF","Gearing M","Nguyen TT","Scanlan J","Linden AV","Dammer EB","Quicksall ZS","Atik M","Yepez G","Mitchell AO","Mayeux R","Marquez DX","Bennett D","Levey AI","Seifar F","Oatman SR","Serrano GE","Wingo A","Seshadri S","Fox EJ","Poehlman WL","Modeste ES","Wingo T","Runnels A","Allen M","Xiao H","Beach TG","Yin L"],"additional_accession":[]},"is_claimable":false,"name":"Bridging the gap: Multi-omics profiling of brain tissue in Alzheimer's disease and older controls in multi-ethnic populations.","description":"<h4>Introduction</h4>Multi-omics studies in Alzheimer's disease (AD) revealed many potential disease pathways and therapeutic targets. Despite their promise of precision medicine, these studies lacked Black Americans (BA) and Latin Americans (LA), who are disproportionately affected by AD.<h4>Methods</h4>To bridge this gap, Accelerating Medicines Partnership in Alzheimer's Disease (AMP-AD) expanded brain multi-omics profiling to multi-ethnic donors.<h4>Results</h4>We generated multi-omics data and curated and harmonized phenotypic data from BA (n = 306), LA (n = 326), or BA and LA (n = 4) brain donors plus non-Hispanic White (n = 252) and other (n = 20) ethnic groups, to establish a foundational dataset enriched for BA and LA participants. This study describes the data available to the res","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T12:59:57.579Z","creation":"2025-04-04T22:47:48.607Z"},"accession":"S-EPMC11485084","cross_references":{"pubmed":["39215503"],"doi":["10.1002/alz.14208"]}}