biostudies-literatureUnknown65(11)St-Jean GDevelopment of gonadal tumors within an ovotestis is rare in mammals and this disturbance was not reported in cows. We report herein a gonadal stromal (granulosa cell) tumor in an ovotestis of a 15-month-old heifer from which the reproductive tract was obtained from a local slaughterhouse. Histopathological evaluation revealed that the gonads were ovotestis, but also a coincidental sex cordstromal (granulosa cell) tumor. The sex chromosome type was determined to be XX, suggesting an XX ovotesticular disorder of sexual development with uterus and a female phenotype. Key clinical message: Disorders of sexual development are common in mammals. Gonadal tumors in disorders of sexual development are rarely reported and have not been reported in cows.The Canadian veterinary journal = La revue veterinaire canadienne1141-1148https://www.ebi.ac.uk/biostudies/studies/S-EPMC11486109biostudies-literatureSex cord-stromal (granulosa cell) tumor in an ovotestis from a cow.PMC11486109Beaudoin GBoyer AZamberlam GCharreton-Sanford VPesant MJGagnon CASt-Jean GfalseSex cord-stromal (granulosa cell) tumor in an ovotestis from a cow.Development of gonadal tumors within an ovotestis is rare in mammals and this disturbance was not reported in cows. We report herein a gonadal stromal (granulosa cell) tumor in an ovotestis of a 15-month-old heifer from which the reproductive tract was obtained from a local slaughterhouse. Histopathological evaluation revealed that the gonads were ovotestis, but also a coincidental sex cordstromal (granulosa cell) tumor. The sex chromosome type was determined to be XX, suggesting an XX ovotesticular disorder of sexual development with uterus and a female phenotype. Key clinical message: Disorders of sexual development are common in mammals. Gonadal tumors in disorders of sexual development are rarely reported and have not been reported in cows.2024-01-01T00:00:00Z2024 Nov2025-04-05T10:19:01.962Z2025-04-05T10:19:01.962ZS-EPMC1148610939494182