{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["Natural Science Foundation of Shanghai","Shanghai Frontiers Research Centre of the Hadal Biosphere"],"pagination":["2412865"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11486183"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(1)"],"pubmed_abstract":["1'-Hydroxy-4',8,8'-trimethoxy-[2,2'-binaphthalene]-1,4-dione (compound <b>5</b>), a secondary metabolite recently discovered in marine fungi, demonstrates promising cytotoxic and anticancer potential. However, knowledge regarding the anticancer activities and biological mechanisms of its derivatives remains limited. Herein, a series of novel naphthoquinone-naphthol derivatives were designed, synthesised, and evaluated for their anticancer activity against cancer cells of different origins. Among these, Compound <b>13</b>, featuring an oxopropyl group at the <i>ortho</i>-position of quinone group, exhibited the most potent inhibitory effects on HCT116, PC9, and A549 cells, with IC<sub>50</sub> values decreasing from 5.27 to 1.18 μM (4.5-fold increase), 6.98 to 0.57 μM (12-fold increase), an"],"journal":["Journal of enzyme inhibition and medicinal chemistry"],"pubmed_title":["Design, synthesis and biological evaluation of marine naphthoquinone-naphthol derivatives as potential anticancer agents."],"pmcid":["PMC11486183"],"funding_grant_id":["21ZR1427300"],"pubmed_authors":["Li Y","Yelv L","Zhu Y","Liu N","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Design, synthesis and biological evaluation of marine naphthoquinone-naphthol derivatives as potential anticancer agents.","description":"1'-Hydroxy-4',8,8'-trimethoxy-[2,2'-binaphthalene]-1,4-dione (compound <b>5</b>), a secondary metabolite recently discovered in marine fungi, demonstrates promising cytotoxic and anticancer potential. However, knowledge regarding the anticancer activities and biological mechanisms of its derivatives remains limited. Herein, a series of novel naphthoquinone-naphthol derivatives were designed, synthesised, and evaluated for their anticancer activity against cancer cells of different origins. Among these, Compound <b>13</b>, featuring an oxopropyl group at the <i>ortho</i>-position of quinone group, exhibited the most potent inhibitory effects on HCT116, PC9, and A549 cells, with IC<sub>50</sub> values decreasing from 5.27 to 1.18 μM (4.5-fold increase), 6.98 to 0.57 μM (12-fold increase), an","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-18T13:09:45.742Z","creation":"2025-04-06T22:42:44.679Z"},"accession":"S-EPMC11486183","cross_references":{"pubmed":["39404032"],"doi":["10.1080/14756366.2024.2412865"]}}