biostudies-literatureNunomura SNHLBI NIH HHS111933https://www.ebi.ac.uk/biostudies/studies/S-EPMC11486451biostudies-literatureUnknown42(1)Atopic dermatitis (AD) is a chronic relapsing skin disease accompanied by recurrent itching. Although type 2 inflammation is dominant in allergic skin inflammation, it is not fully understood how non-type 2 inflammation co-exists with type 2 inflammation or how type 2 inflammation causes itching. We have recently established the FADS mouse, a mouse model of AD. In FADS mice, either genetic disruption or pharmacological inhibition of periostin, a downstream molecule of type 2 inflammation, inhibits NF-κB activation in keratinocytes, leading to downregulating eczema, epidermal hyperplasia, and infiltration of neutrophils, without regulating the enhanced type 2 inflammation. Moreover, inhibition of periostin blocks spontaneous firing of superficial dorsal horn neurons followed by a decrease iCell reportsPeriostin activates distinct modules of inflammation and itching downstream of the type 2 inflammation pathway.PMC11486451R01 HL060714R01 HL148165Nanri YUta DEjiri NIzuhara KYamamoto SKoga MNunomura SIkemitsu HKitajima IConway SJTakedomi HHonda YAndoh TMatsuda KKitajima MfalsePeriostin activates distinct modules of inflammation and itching downstream of the type 2 inflammation pathway.Atopic dermatitis (AD) is a chronic relapsing skin disease accompanied by recurrent itching. Although type 2 inflammation is dominant in allergic skin inflammation, it is not fully understood how non-type 2 inflammation co-exists with type 2 inflammation or how type 2 inflammation causes itching. We have recently established the FADS mouse, a mouse model of AD. In FADS mice, either genetic disruption or pharmacological inhibition of periostin, a downstream molecule of type 2 inflammation, inhibits NF-κB activation in keratinocytes, leading to downregulating eczema, epidermal hyperplasia, and infiltration of neutrophils, without regulating the enhanced type 2 inflammation. Moreover, inhibition of periostin blocks spontaneous firing of superficial dorsal horn neurons followed by a decrease i2023-01-01T00:00:00Z2023 Jan2025-04-26T13:57:03.591Z2025-04-06T14:24:29.185ZS-EPMC114864513661039610.1016/j.celrep.2022.111933