{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Montorsi RM"],"pubmed_abstract":["<h4>Background</h4>Post-pancreatectomy hemorrhage (PPH) is a leading cause for surgical mortality after pancreatic surgery. Several strategies for the prevention and management of PPH have been studied in randomized controlled trials (RCTs) but a systematic review is lacking. We systematically reviewed RCTs regarding the impact of treatment strategies on the incidence and outcome of PPH.<h4>Material and methods</h4>Eligible RCTs reporting on impact of treatment on the rate of PPH were identified through a systematic literature search using the Evidence Map of Pancreatic Surgery (2012-2022). Methodological quality was assessed using the Cochrane Risk of Bias 2 (RoB-2) tool for RCTs. Various definitions of PPH were accepted and outcome reported separately for the International Study Group fo"],"journal":["International journal of surgery (London, England)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11486935"],"repository":["biostudies-literature"],"pubmed_title":["Treatment strategies to prevent or mitigate the outcome of post-pancreatectomy hemorrhage (PPH): a review of randomized trials."],"pmcid":["PMC11486935"],"pubmed_authors":["Zonderhuis BM","Malleo G","Daams F","Montorsi RM","Busch OR","Besselink MG","Salvia R","Marchegiani G","Kazemier G"],"additional_accession":[]},"is_claimable":false,"name":"Treatment strategies to prevent or mitigate the outcome of post-pancreatectomy hemorrhage (PPH): a review of randomized trials.","description":"<h4>Background</h4>Post-pancreatectomy hemorrhage (PPH) is a leading cause for surgical mortality after pancreatic surgery. Several strategies for the prevention and management of PPH have been studied in randomized controlled trials (RCTs) but a systematic review is lacking. We systematically reviewed RCTs regarding the impact of treatment strategies on the incidence and outcome of PPH.<h4>Material and methods</h4>Eligible RCTs reporting on impact of treatment on the rate of PPH were identified through a systematic literature search using the Evidence Map of Pancreatic Surgery (2012-2022). Methodological quality was assessed using the Cochrane Risk of Bias 2 (RoB-2) tool for RCTs. Various definitions of PPH were accepted and outcome reported separately for the International Study Group fo","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-04T14:36:50.967Z","creation":"2025-04-04T14:36:50.967Z"},"accession":"S-EPMC11486935","cross_references":{"pubmed":["37983766"],"doi":["10.1097/JS9.0000000000000876"]}}