biostudies-literatureUnknownMontorsi RM<h4>Background</h4>Post-pancreatectomy hemorrhage (PPH) is a leading cause for surgical mortality after pancreatic surgery. Several strategies for the prevention and management of PPH have been studied in randomized controlled trials (RCTs) but a systematic review is lacking. We systematically reviewed RCTs regarding the impact of treatment strategies on the incidence and outcome of PPH.<h4>Material and methods</h4>Eligible RCTs reporting on impact of treatment on the rate of PPH were identified through a systematic literature search using the Evidence Map of Pancreatic Surgery (2012-2022). Methodological quality was assessed using the Cochrane Risk of Bias 2 (RoB-2) tool for RCTs. Various definitions of PPH were accepted and outcome reported separately for the International Study Group foInternational journal of surgery (London, England)https://www.ebi.ac.uk/biostudies/studies/S-EPMC11486935biostudies-literatureTreatment strategies to prevent or mitigate the outcome of post-pancreatectomy hemorrhage (PPH): a review of randomized trials.PMC11486935Zonderhuis BMMalleo GDaams FMontorsi RMBusch ORBesselink MGSalvia RMarchegiani GKazemier GfalseTreatment strategies to prevent or mitigate the outcome of post-pancreatectomy hemorrhage (PPH): a review of randomized trials.<h4>Background</h4>Post-pancreatectomy hemorrhage (PPH) is a leading cause for surgical mortality after pancreatic surgery. Several strategies for the prevention and management of PPH have been studied in randomized controlled trials (RCTs) but a systematic review is lacking. We systematically reviewed RCTs regarding the impact of treatment strategies on the incidence and outcome of PPH.<h4>Material and methods</h4>Eligible RCTs reporting on impact of treatment on the rate of PPH were identified through a systematic literature search using the Evidence Map of Pancreatic Surgery (2012-2022). Methodological quality was assessed using the Cochrane Risk of Bias 2 (RoB-2) tool for RCTs. Various definitions of PPH were accepted and outcome reported separately for the International Study Group fo2023-01-01T00:00:00Z2023 Nov2025-04-04T14:36:50.967Z2025-04-04T14:36:50.967ZS-EPMC114869353798376610.1097/JS9.0000000000000876