biostudies-literatureVoutouri CEuropean Research CouncilEC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)203https://www.ebi.ac.uk/biostudies/studies/S-EPMC11487255biostudies-literatureUnknown4(1)<h4>Background</h4>In the era of personalized cancer treatment, understanding the intrinsic heterogeneity of tumors is crucial. Despite some patients responding favorably to a particular treatment, others may not benefit, leading to the varied efficacy observed in standard therapies. This study focuses on the prediction of tumor response to chemo-immunotherapy, exploring the potential of tumor mechanics and medical imaging as predictive biomarkers. We have extensively studied "desmoplastic" tumors, characterized by a dense and very stiff stroma, which presents a substantial challenge for treatment. The increased stiffness of such tumors can be restored through pharmacological intervention with mechanotherapeutics.<h4>Methods</h4>We developed a deep learning methodology based on shear wave Communications medicineA convolutional attention model for predicting response to chemo-immunotherapy from ultrasound elastography in mouse tumor models.PMC11487255956201101069207Englezos DStrouthos IVoutouri CStylianopoulos TZamboglou CPapanastasiou GfalseA convolutional attention model for predicting response to chemo-immunotherapy from ultrasound elastography in mouse tumor models.<h4>Background</h4>In the era of personalized cancer treatment, understanding the intrinsic heterogeneity of tumors is crucial. Despite some patients responding favorably to a particular treatment, others may not benefit, leading to the varied efficacy observed in standard therapies. This study focuses on the prediction of tumor response to chemo-immunotherapy, exploring the potential of tumor mechanics and medical imaging as predictive biomarkers. We have extensively studied "desmoplastic" tumors, characterized by a dense and very stiff stroma, which presents a substantial challenge for treatment. The increased stiffness of such tumors can be restored through pharmacological intervention with mechanotherapeutics.<h4>Methods</h4>We developed a deep learning methodology based on shear wave 2024-01-01T00:00:00Z2024 Oct2026-06-01T09:14:52.637Z2025-04-04T09:58:23.201ZS-EPMC114872553942019910.1038/s43856-024-00634-4