biostudies-literatureTowns CCure Parkinson's TrustMedical Research CouncilJanet Owens bequest fundNational Institute for Health Research (NIHR)Global Parkinson’s Genetics ProgramCure Parkinson’s TrustWellcome Trust188https://www.ebi.ac.uk/biostudies/studies/S-EPMC11487259biostudies-literatureUnknown10(1)The Parkinson's Families Project is a UK-wide study aimed at identifying genetic variation associated with familial and early-onset Parkinson's disease (PD). We recruited individuals with a clinical diagnosis of PD and age at motor symptom onset ≤45 years and/or a family history of PD in up to third-degree relatives. Where possible, we also recruited affected and unaffected relatives. We analysed DNA samples with a combination of single nucleotide polymorphism (SNP) array genotyping, multiplex ligation-dependent probe amplification (MLPA), and whole-genome sequencing (WGS). We investigated the association between identified pathogenic mutations and demographic and clinical factors such as age at motor symptom onset, family history, motor symptoms (MDS-UPDRS) and cognitive performance (MoCANPJ Parkinson's diseaseParkinson's families project: a UK-wide study of early onset and familial Parkinson's disease.PMC11487259G0700943Bandmann OSveinbjornsdottir SPadiachy DWu LRaw JAsad SSchmaderer TMDean SHodgson MGentilini ILange LMWood NWChaudhuri RWickremaratchi MHand ABuccoliero RMisbahuddin AWiblin LMolloy SGuptha SHoulden HLabrum RWebster GNacorda AStafford EJWalker RGlobal Parkinson’s Genetics Program (GP2)Polke JArchibald NJasaityte SKunc MBhatia KPTan MMXSchrag AParkinson’s Families Project (PFP) Study GroupStrens LHartley LPollard MCapps EBarnes CMorris HRJones SWilliams SPaviour DCosgrove JShaik SD'Costa DJones ESheridan RTuck SBlauwendraat CFang ZHArianayagam STowns CVickers CReal RNath UBrierley CSophia RSingleton ABTilney RSaifee TFunaki AJarman PRSchapira AHVWakeman EGregory RAmar KWales ETruscott RSlaght SJCrouch RKlein CTai YMann CHehir JfalseParkinson's families project: a UK-wide study of early onset and familial Parkinson's disease.The Parkinson's Families Project is a UK-wide study aimed at identifying genetic variation associated with familial and early-onset Parkinson's disease (PD). We recruited individuals with a clinical diagnosis of PD and age at motor symptom onset ≤45 years and/or a family history of PD in up to third-degree relatives. Where possible, we also recruited affected and unaffected relatives. We analysed DNA samples with a combination of single nucleotide polymorphism (SNP) array genotyping, multiplex ligation-dependent probe amplification (MLPA), and whole-genome sequencing (WGS). We investigated the association between identified pathogenic mutations and demographic and clinical factors such as age at motor symptom onset, family history, motor symptoms (MDS-UPDRS) and cognitive performance (MoCA2024-01-01T00:00:00Z2024 Oct2026-07-15T13:04:18.566Z2025-04-04T22:47:48.008ZS-EPMC114872593942003410.1038/s41531-024-00778-z