biostudies-literatureUnknownPewklang TThe Robert A. Welch FoundationNINDS NIH HHSNational Institutes of HealthTexas A and M UniversityNeurotrophins (NTs) elicit the growth, survival, and differentiation of neurons and other neuroectoderm tissues via activation of Trk receptors. Hot spots for NT·Trk interactions involve three neurotrophin loops. Mimicry of these using "<i>cyclo</i>-organopeptides" comprising loop sequences cyclized onto endocyclic organic fragments accounts for a few of the low molecular mass Trk agonists or modulators reported so far; the majority are nonpeptidic small molecules accessed without molecular design and identified in random screens. It has proven difficult to verify activities induced by low molecular mass substances are due to Trk activation (rather than via other receptors), enhanced Trk expression, enhanced NT expression, or other pathways. Consequently, identification of selective probesACS chemical neurosciencehttps://www.ebi.ac.uk/biostudies/studies/S-EPMC11487604biostudies-literatureSelective, Intrinsically Fluorescent Trk Modulating Probes.PMC11487604R21NS1304711R21NS13834-01A1R01 NS128101R21 NS130471R01EY029645AU-2182-20240404246292-00000R21 NS131834NIH R21NS130471Sefiani AKamkaew APewklang TBurgess KGeoffroy CGThompson TfalseSelective, Intrinsically Fluorescent Trk Modulating Probes.Neurotrophins (NTs) elicit the growth, survival, and differentiation of neurons and other neuroectoderm tissues via activation of Trk receptors. Hot spots for NT·Trk interactions involve three neurotrophin loops. Mimicry of these using "<i>cyclo</i>-organopeptides" comprising loop sequences cyclized onto endocyclic organic fragments accounts for a few of the low molecular mass Trk agonists or modulators reported so far; the majority are nonpeptidic small molecules accessed without molecular design and identified in random screens. It has proven difficult to verify activities induced by low molecular mass substances are due to Trk activation (rather than via other receptors), enhanced Trk expression, enhanced NT expression, or other pathways. Consequently, identification of selective probes2024-01-01T00:00:00Z2024 Oct2026-07-15T12:59:20.156Z2025-04-04T22:47:29.428ZS-EPMC114876043935621510.1021/acschemneuro.4c00290