biostudies-literatureUnknown22(1)Lowenmark TUmea University<h4>Background</h4>Mounting evidence suggests a significant role of the gut microbiota in the development and progression of colorectal cancer (CRC). In particular, an over-representation of oral pathogens has been linked to CRC. The aim of this study was to further investigate the faecal microbial landscape of CRC patients, with a focus on the oral pathogens Parvimonas micra and Fusobacterium nucleatum.<h4>Methods</h4>In this study, 16S rRNA sequencing was conducted using faecal samples from CRC patients (n = 275) and controls without pathological findings (n = 95).<h4>Results</h4>We discovered a significant difference in microbial composition depending on tumour location and microsatellite instability (MSI) status, with P. micra, F. nucleatum, and Peptostreptococcus stomatis found to be Journal of translational medicine947https://www.ebi.ac.uk/biostudies/studies/S-EPMC11487773biostudies-literatureParvimonas micra forms a distinct bacterial network with oral pathobionts in colorectal cancer patients.PMC11487773Wai SNPalmqvist RLowenmark TBronnec VLarsson PEdin SLofgren-Burstrom AZingmark CDahlberg MRosenbaum WSchroeder BOLjuslinder IKohn LKellgren TfalseParvimonas micra forms a distinct bacterial network with oral pathobionts in colorectal cancer patients.<h4>Background</h4>Mounting evidence suggests a significant role of the gut microbiota in the development and progression of colorectal cancer (CRC). In particular, an over-representation of oral pathogens has been linked to CRC. The aim of this study was to further investigate the faecal microbial landscape of CRC patients, with a focus on the oral pathogens Parvimonas micra and Fusobacterium nucleatum.<h4>Methods</h4>In this study, 16S rRNA sequencing was conducted using faecal samples from CRC patients (n = 275) and controls without pathological findings (n = 95).<h4>Results</h4>We discovered a significant difference in microbial composition depending on tumour location and microsatellite instability (MSI) status, with P. micra, F. nucleatum, and Peptostreptococcus stomatis found to be 2024-01-01T00:00:00Z2024 Oct2025-04-04T19:45:38.293Z2025-04-04T19:45:38.293ZS-EPMC114877733942033310.1186/s12967-024-05720-8