{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(16)"],"submitter":["Cheng K"],"pubmed_abstract":["C-X-C motif chemokine receptor 4 (CXCR4) is an attractive target for the diagnosis and treatment of cancers. Here, we aimed to develop a new CXCR4-targeted PET tracer, and to investigate the translational potential for noninvasive imaging of CXCR4 expression in various cancer entities through preclinical and pilot clinical studies. <b>Methods</b> [<sup>18</sup>F]AlF-NOTA-QHY-04 was synthesized and evaluated by cellular uptake, blocking and biolayer interferometry studies <i>in vitro</i>. The pharmacokinetics, biodistribution, and imaging specificity were researched in tumor-bearing mice. [<sup>18</sup>F]AlF-NOTA-QHY-04 PET/CT imaging was performed on 55 patients with different types of cancers. Correlations between <i>ex vivo</i> CXCR4 expression and PET parameters, and CXCR4 expression ch"],"journal":["Theranostics"],"pagination":["6337-6349"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11488100"],"repository":["biostudies-literature"],"pubmed_title":["PET imaging of CXCR4 expression using [&lt;sup&gt;18&lt;/sup&gt;F]AlF-NOTA-QHY-04 for hematologic malignancy and solid tumors."],"pmcid":["PMC11488100"],"pubmed_authors":["Liu J","Wang S","Cheng K","Pei J","Xu S","Luo Y","Liu T","Zhao K","Yu J"],"additional_accession":[]},"is_claimable":false,"name":"PET imaging of CXCR4 expression using [&lt;sup&gt;18&lt;/sup&gt;F]AlF-NOTA-QHY-04 for hematologic malignancy and solid tumors.","description":"C-X-C motif chemokine receptor 4 (CXCR4) is an attractive target for the diagnosis and treatment of cancers. Here, we aimed to develop a new CXCR4-targeted PET tracer, and to investigate the translational potential for noninvasive imaging of CXCR4 expression in various cancer entities through preclinical and pilot clinical studies. <b>Methods</b> [<sup>18</sup>F]AlF-NOTA-QHY-04 was synthesized and evaluated by cellular uptake, blocking and biolayer interferometry studies <i>in vitro</i>. The pharmacokinetics, biodistribution, and imaging specificity were researched in tumor-bearing mice. [<sup>18</sup>F]AlF-NOTA-QHY-04 PET/CT imaging was performed on 55 patients with different types of cancers. Correlations between <i>ex vivo</i> CXCR4 expression and PET parameters, and CXCR4 expression ch","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-04T19:45:45.129Z","creation":"2025-04-04T19:45:45.129Z"},"accession":"S-EPMC11488100","cross_references":{"pubmed":["39431004"],"doi":["10.7150/thno.99025"]}}