{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shi Z"],"funding":["the Xinjiang Tianshan Talent Training Program Grant","the National Natural Science Foundation of China regional project","the Xinjiang Natural Science Foundation for Distinguished Young Scholars"],"pagination":["179"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11488200"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(1)"],"pubmed_abstract":["<h4>Background</h4>Docetaxel (DTX) resistance attenuates anti-tumor effects of DTX on prostate cancer (mCRPC) and drug resistance was related to Treg expansion in tumors. ZNF667-AS1 played a suppressing role in various tumors and tumor-derived exosomes carry lncRNAs to participate in tumor progression. Here, the effects of ZNF667-AS1 on malignant characteristics and DTX resistance in PC and the effect and its underlying molecular mechanism of tumor-derived exosomes carrying ZNF667-AS1 on Treg expansion were investigated.<h4>Methods</h4>The identification of exosomes were determined using TEM, NTA and western blot. The abundance of genes and proteins were evaluated using IHC, RT-qPCR, western blot and FISH. Malignant phenotypes of PC cells were evaluated by means of Edu, scratch test, trans"],"journal":["Molecular medicine (Cambridge, Mass.)"],"pubmed_title":["Prostate cancer cell-derived exosomes ZNF667-AS1 reduces TGFBR1 mRNA stability to inhibit Treg expansion and DTX resistance by binding to U2AF1."],"pmcid":["PMC11488200"],"funding_grant_id":["82360520","2023TSYCCX0061","2022D01E84"],"pubmed_authors":["Sun M","Li J","Li Z","Aihemaitijiang M","Li S","Zhang X","Pu W","Liu B","Shi Z","Li M"],"additional_accession":[]},"is_claimable":false,"name":"Prostate cancer cell-derived exosomes ZNF667-AS1 reduces TGFBR1 mRNA stability to inhibit Treg expansion and DTX resistance by binding to U2AF1.","description":"<h4>Background</h4>Docetaxel (DTX) resistance attenuates anti-tumor effects of DTX on prostate cancer (mCRPC) and drug resistance was related to Treg expansion in tumors. ZNF667-AS1 played a suppressing role in various tumors and tumor-derived exosomes carry lncRNAs to participate in tumor progression. Here, the effects of ZNF667-AS1 on malignant characteristics and DTX resistance in PC and the effect and its underlying molecular mechanism of tumor-derived exosomes carrying ZNF667-AS1 on Treg expansion were investigated.<h4>Methods</h4>The identification of exosomes were determined using TEM, NTA and western blot. The abundance of genes and proteins were evaluated using IHC, RT-qPCR, western blot and FISH. Malignant phenotypes of PC cells were evaluated by means of Edu, scratch test, trans","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T02:21:16.075Z","creation":"2025-04-04T02:21:16.075Z"},"accession":"S-EPMC11488200","cross_references":{"pubmed":["39425009"],"doi":["10.1186/s10020-024-00947-z"]}}