{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hass R"],"funding":["Medizinische Hochschule Hannover (MHH)","NDR charity campaign"],"pagination":["506"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11488203"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Background
The release of extracellular vesicles (EVs) including exosomes from human mesenchymal stroma/stem-like cells (MSC) represents valuable cell-free carriers for the delivery of regenerative and medicinal compounds.Methods
EVs/exosomes were isolated by differential centrifugation from four individual MSC as controls and after treatment with a sub-lethal concentration of 10 mM taxol for 24 h, respectively. The isolated EVs/exosomes were characterized and quantified by nano-tracking-analysis and by Western blots. MicroRNAs (miRs) were isolated from the different EVs/exosome populations and expression levels were quantified by qPCR using 1246 miR templates. Cytotoxic effects of the different MSC-derived taxol-loaded EVs/exosomes were determined in five different GFP-tra"],"journal":["Cell communication and signaling : CCS"],"pubmed_title":["Human mesenchymal stroma/stem-like cell-derived taxol-loaded EVs/exosomes transfer anti-tumor microRNA signatures and express enhanced SDF-1-mediated tumor tropism."],"pmcid":["PMC11488203"],"funding_grant_id":["'Hand in Hand für Norddeutschland 2019'","‘Hand in Hand für Norddeutschland 2019’"],"pubmed_authors":["von der Ohe J","Hass R","Luo T"],"additional_accession":[]},"is_claimable":false,"name":"Human mesenchymal stroma/stem-like cell-derived taxol-loaded EVs/exosomes transfer anti-tumor microRNA signatures and express enhanced SDF-1-mediated tumor tropism.","description":"Background
The release of extracellular vesicles (EVs) including exosomes from human mesenchymal stroma/stem-like cells (MSC) represents valuable cell-free carriers for the delivery of regenerative and medicinal compounds.Methods
EVs/exosomes were isolated by differential centrifugation from four individual MSC as controls and after treatment with a sub-lethal concentration of 10 mM taxol for 24 h, respectively. The isolated EVs/exosomes were characterized and quantified by nano-tracking-analysis and by Western blots. MicroRNAs (miRs) were isolated from the different EVs/exosome populations and expression levels were quantified by qPCR using 1246 miR templates. Cytotoxic effects of the different MSC-derived taxol-loaded EVs/exosomes were determined in five different GFP-tra","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T04:57:52.714Z","creation":"2025-04-04T02:21:27.757Z"},"accession":"S-EPMC11488203","cross_references":{"pubmed":["39420354"],"doi":["10.1186/s12964-024-01886-2"]}}