{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu SH"],"funding":["Ministry of Science and Technology, Taiwan","Taipei Veterans General Hospital","Ministry of Health and Welfare","Taoyuan General Hospital"],"pagination":["837-849"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11488484"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26"],"pubmed_abstract":["We compared infant bone marrow-derived mesenchymal stem cells (infant BMSCs) with umbilical cord-derived mesenchymal stem cells (UCSCs) by assessing multilineage differentiation. Proliferation was gauged through changes in cell numbers and doubling time. Senescence-related genes (<i>p16</i>, <i>p21</i>, and <i>p53</i>), senescence-associated β-galactosidase (SA-β-gal), and γH2AX immunofluorescence determined senescence presence. Superoxide dismutases (SODs) and genes related to various differentiations were analyzed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Differentiation was confirmed through histochemical, immunohistochemical, and immunofluorescence staining. Infant BMSCs surpassed UCSCs in proliferation. Infant BMSCs exhibited lower senescence-relate"],"journal":["Regenerative therapy"],"pubmed_title":["Comparison of infant bone marrow- and umbilical cord-derived mesenchymal stem cells in multilineage differentiation."],"pmcid":["PMC11488484"],"funding_grant_id":["V111C-231","111-2314-B-075-057-MY3","PTH111063"],"pubmed_authors":["Liao YT","Wang JP","Hsueh KK","Chou PH","Wu SH","Yu JH","Wen MH"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of infant bone marrow- and umbilical cord-derived mesenchymal stem cells in multilineage differentiation.","description":"We compared infant bone marrow-derived mesenchymal stem cells (infant BMSCs) with umbilical cord-derived mesenchymal stem cells (UCSCs) by assessing multilineage differentiation. Proliferation was gauged through changes in cell numbers and doubling time. Senescence-related genes (<i>p16</i>, <i>p21</i>, and <i>p53</i>), senescence-associated β-galactosidase (SA-β-gal), and γH2AX immunofluorescence determined senescence presence. Superoxide dismutases (SODs) and genes related to various differentiations were analyzed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Differentiation was confirmed through histochemical, immunohistochemical, and immunofluorescence staining. Infant BMSCs surpassed UCSCs in proliferation. Infant BMSCs exhibited lower senescence-relate","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-06-24T03:10:09.749Z","creation":"2025-04-04T19:46:02.936Z"},"accession":"S-EPMC11488484","cross_references":{"pubmed":["39430580"],"doi":["10.1016/j.reth.2024.09.011"]}}