{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(42)"],"submitter":["Bing RG"],"pubmed_abstract":["Renewable alternatives for nonelectrifiable fossil-derived chemicals are needed and plant matter, the most abundant biomass on Earth, provide an ideal feedstock. However, the heterogeneous polymeric composition of lignocellulose makes conversion difficult. Lignin presents a formidable barrier to fermentation of nonpretreated biomass. Extensive chemical and enzymatic treatments can liberate fermentable carbohydrates from plant biomass, but microbial routes offer many advantages, including concomitant conversion to industrial chemicals. Here, testing of lignin content of nonpretreated biomass using the cellulolytic thermophilic bacterium, <i>Anaerocellum bescii</i>, revealed that the primary microbial degradation barrier relates to methoxy substitutions in lignin. This contrasts with optimal"],"journal":["Science advances"],"pagination":["eadq4941"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11488576"],"repository":["biostudies-literature"],"pubmed_title":["Beyond low lignin: Identifying the primary barrier to plant biomass conversion by fermentative bacteria."],"pmcid":["PMC11488576"],"pubmed_authors":["Wang JP","Willard DJ","Adams MWW","Sulis DB","Manesh MJH","Alexander BH","Yang C","Carey MJ","Ford KC","Bing RG","Straub CT","Jiang X","Laemthong T","Kelly RM"],"additional_accession":[]},"is_claimable":false,"name":"Beyond low lignin: Identifying the primary barrier to plant biomass conversion by fermentative bacteria.","description":"Renewable alternatives for nonelectrifiable fossil-derived chemicals are needed and plant matter, the most abundant biomass on Earth, provide an ideal feedstock. However, the heterogeneous polymeric composition of lignocellulose makes conversion difficult. Lignin presents a formidable barrier to fermentation of nonpretreated biomass. Extensive chemical and enzymatic treatments can liberate fermentable carbohydrates from plant biomass, but microbial routes offer many advantages, including concomitant conversion to industrial chemicals. Here, testing of lignin content of nonpretreated biomass using the cellulolytic thermophilic bacterium, <i>Anaerocellum bescii</i>, revealed that the primary microbial degradation barrier relates to methoxy substitutions in lignin. This contrasts with optimal","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T20:55:34.516Z","creation":"2025-04-04T20:55:34.516Z"},"accession":"S-EPMC11488576","cross_references":{"pubmed":["39423261"],"doi":["10.1126/sciadv.adq4941"]}}