{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(10)"],"submitter":["Heileson JL"],"pubmed_abstract":["<h4>Background</h4>Accumulating evidence has highlighted the acute and chronic impact of repetitive subconcussive head impacts (rSHIs) in contact sports. Neurofilament-light (Nf-L), a brain-derived biomarker of neuroaxonal injury, elevates in concert with rSHI. Recently, long-chain ω-3 polyunsaturated fatty acids (LC ω-3 PUFAs) supplementation has been suggested to mitigate brain injury from rSHI as reflected by attenuation of Nf-L concentrations within contact sport athletes.<h4>Objective</h4>Using a systematic review with a meta-analysis, we aimed to determine the effect of LC ω-3 PUFA supplementation on Nf-L concentrations in athletes routinely exposed to rSHI.<h4>Methods</h4>Electronic databases (PubMed and CINAHL) were searched from inception through January 2024. One-stage meta-analy"],"journal":["Current developments in nutrition"],"pagination":["104454"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11489149"],"repository":["biostudies-literature"],"pubmed_title":["Nutritional Optimization for Brain Health in Contact Sports: A Systematic Review and Meta-Analysis on Long-Chain ω-3 Fatty Acids and Neurofilament Light."],"pmcid":["PMC11489149"],"pubmed_authors":["Macartney MJ","Watson NL","Sergi TE","Peoples GE","Anthony R","Heileson JL","Jagim AR"],"additional_accession":[]},"is_claimable":false,"name":"Nutritional Optimization for Brain Health in Contact Sports: A Systematic Review and Meta-Analysis on Long-Chain ω-3 Fatty Acids and Neurofilament Light.","description":"<h4>Background</h4>Accumulating evidence has highlighted the acute and chronic impact of repetitive subconcussive head impacts (rSHIs) in contact sports. Neurofilament-light (Nf-L), a brain-derived biomarker of neuroaxonal injury, elevates in concert with rSHI. Recently, long-chain ω-3 polyunsaturated fatty acids (LC ω-3 PUFAs) supplementation has been suggested to mitigate brain injury from rSHI as reflected by attenuation of Nf-L concentrations within contact sport athletes.<h4>Objective</h4>Using a systematic review with a meta-analysis, we aimed to determine the effect of LC ω-3 PUFA supplementation on Nf-L concentrations in athletes routinely exposed to rSHI.<h4>Methods</h4>Electronic databases (PubMed and CINAHL) were searched from inception through January 2024. One-stage meta-analy","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T02:54:31.164Z","creation":"2025-04-04T02:54:31.164Z"},"accession":"S-EPMC11489149","cross_references":{"pubmed":["39429508"],"doi":["10.1016/j.cdnut.2024.104454"]}}